瑞典SELMA 队列研究：妊娠期EDC混合物与7岁时身体脂肪的关系
2024/05/28
摘要
背景：某些内分泌干扰物（EDC）是 "肥胖原"，被发现与儿童超重和肥胖有关。因此，我们需要采用混合方法对每天接触的不同种类EDC进行研究。
目的：本研究评估了产前暴露于 EDC 混合物与 7 岁儿童体脂之间的关系，并考虑了性别特异性影响。
方法：对总共 26 种 EDC 进行分析：参加瑞典环境纵向、母婴、哮喘和过敏（SELMA）研究的 737 对母婴，采集怀孕头三个月的产前尿液和血清样本，并评估了 26 种 EDC。根据七岁时测量的体重指数、体脂百分比、腰围和皮脂厚度，采用主成分分析法（PCA）计算出儿童的 "总体体脂 "指标。采用加权组合分位数 (WQS) 回归法评估 EDC 混合物与儿童体脂之间的关系。
结果：主成分（PC1）占方差的 83.6%，适合作为儿童 "总体体脂 "的指标，每个体脂指标的正负荷量为 0.40-0.42。一个重要的相互作用项（WQS*性别）证实，男孩和女孩的关联方向相反。男孩产前接触较多的 EDC 混合物与较多的 "总体体脂"（平均 β = 0.20; 95 % CI: -0.13, 0.53）和女孩较少的 "总体体脂"（平均 β = -0.23; 95 % CI: -0.58, 0.13）之间存在临界意义。此外，产前接触较多的 EDC 混合物对男孩体脂百分比（标准化比数）的增加（平均值 β = 0.09；95 % CI：-0.04，0.21）和女孩体脂百分比的减少（平均值 β = -0.10 (-0.26, 0.05)）存在临界意义。男孩和女孩所需要警惕的化学物质（包括双酚类化合物、酞酸酯、PFAS、PAH和杀虫剂）存在不同。
结论：研究发现，产前暴露于EDCs混合物与儿童的体脂之间存在临界相关性意义。这种相反方向的关联表明，产前接触 EDCs 可能会对儿童的体脂产生性别特异性效应。
EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study
Svensson, K., Gennings, C., Lindh, C., Kiviranta, H., Rantakokko, P., Wikström, S., & Bornehag, C. G.
Abstract
Background:Some endocrine disrupting chemicals (EDC), are "obesogens" and have been associated with overweight and obesity in children. Daily exposure to different classes of EDCs demands for research with mixtures approach.
Objectives:This study evaluates the association, considering sex-specific effects, between prenatal exposure to EDC mixture and children's body fat at seven years of age.
Methods:A total of 26 EDCs were assessed in prenatal urine and serum samples from first trimester in pregnancy from 737 mother-child pairs participating in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. An indicator for children's "overall body fat" was calculated, using principal component analysis (PCA), based on BMI, percent body fat, waist, and skinfolds measured at seven years of age. Weighted quantile sum (WQS) regression was used to assess associations between EDC mixture and children's body fat.
Results:Principal component (PC1) represented 83.6 % of the variance, suitable as indicator for children's "overall body fat", with positive loadings of 0.40-0.42 for each body fat measure. A significant interaction term, WQS*sex, confirmed associations in the opposite direction for boys and girls. Higher prenatal exposure to EDC mixture was borderline significant with more "overall body fat" for boys (Mean β = 0.20; 95 % CI: -0.13, 0.53) and less for girls (Mean β = -0.23; 95 % CI: -0.58, 0.13). Also, higher prenatal exposure to EDC mixture was borderline significant with more percent body fat (standardized score) for boys (Mean β = 0.09; 95 % CI: -0.04, 0.21) and less for girls (Mean β = -0.10 (-0.26, 0.05). The chemicals of concern included bisphenols, phthalates, PFAS, PAH, and pesticides with different patterns for boys and girls.
Conclusion:Borderline significant associations were found between prenatal exposure to a mixture of EDCs and children's body fat. The associations in opposite directions suggests that prenatal exposure to EDCs may present sex-specific effects on children's body fat.
背景：某些内分泌干扰物（EDC）是 "肥胖原"，被发现与儿童超重和肥胖有关。因此，我们需要采用混合方法对每天接触的不同种类EDC进行研究。
目的：本研究评估了产前暴露于 EDC 混合物与 7 岁儿童体脂之间的关系，并考虑了性别特异性影响。
方法：对总共 26 种 EDC 进行分析：参加瑞典环境纵向、母婴、哮喘和过敏（SELMA）研究的 737 对母婴，采集怀孕头三个月的产前尿液和血清样本，并评估了 26 种 EDC。根据七岁时测量的体重指数、体脂百分比、腰围和皮脂厚度，采用主成分分析法（PCA）计算出儿童的 "总体体脂 "指标。采用加权组合分位数 (WQS) 回归法评估 EDC 混合物与儿童体脂之间的关系。
结果：主成分（PC1）占方差的 83.6%，适合作为儿童 "总体体脂 "的指标，每个体脂指标的正负荷量为 0.40-0.42。一个重要的相互作用项（WQS*性别）证实，男孩和女孩的关联方向相反。男孩产前接触较多的 EDC 混合物与较多的 "总体体脂"（平均 β = 0.20; 95 % CI: -0.13, 0.53）和女孩较少的 "总体体脂"（平均 β = -0.23; 95 % CI: -0.58, 0.13）之间存在临界意义。此外，产前接触较多的 EDC 混合物对男孩体脂百分比（标准化比数）的增加（平均值 β = 0.09；95 % CI：-0.04，0.21）和女孩体脂百分比的减少（平均值 β = -0.10 (-0.26, 0.05)）存在临界意义。男孩和女孩所需要警惕的化学物质（包括双酚类化合物、酞酸酯、PFAS、PAH和杀虫剂）存在不同。
结论：研究发现，产前暴露于EDCs混合物与儿童的体脂之间存在临界相关性意义。这种相反方向的关联表明，产前接触 EDCs 可能会对儿童的体脂产生性别特异性效应。
(中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校)
(Environ Res. 2024 May 1; DOI: 10.1016/j.envres.2024.118293)
(Environ Res. 2024 May 1; DOI: 10.1016/j.envres.2024.118293)
EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study
Svensson, K., Gennings, C., Lindh, C., Kiviranta, H., Rantakokko, P., Wikström, S., & Bornehag, C. G.
Abstract
Background:Some endocrine disrupting chemicals (EDC), are "obesogens" and have been associated with overweight and obesity in children. Daily exposure to different classes of EDCs demands for research with mixtures approach.
Objectives:This study evaluates the association, considering sex-specific effects, between prenatal exposure to EDC mixture and children's body fat at seven years of age.
Methods:A total of 26 EDCs were assessed in prenatal urine and serum samples from first trimester in pregnancy from 737 mother-child pairs participating in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. An indicator for children's "overall body fat" was calculated, using principal component analysis (PCA), based on BMI, percent body fat, waist, and skinfolds measured at seven years of age. Weighted quantile sum (WQS) regression was used to assess associations between EDC mixture and children's body fat.
Results:Principal component (PC1) represented 83.6 % of the variance, suitable as indicator for children's "overall body fat", with positive loadings of 0.40-0.42 for each body fat measure. A significant interaction term, WQS*sex, confirmed associations in the opposite direction for boys and girls. Higher prenatal exposure to EDC mixture was borderline significant with more "overall body fat" for boys (Mean β = 0.20; 95 % CI: -0.13, 0.53) and less for girls (Mean β = -0.23; 95 % CI: -0.58, 0.13). Also, higher prenatal exposure to EDC mixture was borderline significant with more percent body fat (standardized score) for boys (Mean β = 0.09; 95 % CI: -0.04, 0.21) and less for girls (Mean β = -0.10 (-0.26, 0.05). The chemicals of concern included bisphenols, phthalates, PFAS, PAH, and pesticides with different patterns for boys and girls.
Conclusion:Borderline significant associations were found between prenatal exposure to a mixture of EDCs and children's body fat. The associations in opposite directions suggests that prenatal exposure to EDCs may present sex-specific effects on children's body fat.
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