鼻病毒激发后生物标记物波动动态显示哮喘患者适应能力丧失
2020/01/07
摘要
哮喘是一种动态的疾病，肺内的机械和炎症过程以复杂的方式相互作用，常常导致过度的生理反应，特别是对外源性刺激的炎症反应。我们假设这可能是由于呼吸系统疾病相关的稳态失衡和对不断变化的环境条件的适应性丧失所致，表现为生物标志物和症状的高度波动。利用炎性（嗜酸性粒细胞、中性粒细胞、FeNO）、临床和肺功能生物标记物（PEF、FVC、FEV1）的时间序列，我们评估了24名健康和哮喘志愿者在实验性鼻病毒感染期间的适应能力是否丧失。通过比较激发前和激发后时间序列的相似性来评估适应能力是否受损。与健康受试者不同，哮喘患者的病毒激发后状态与其他鼻病毒感染的哮喘患者相似，但并非是其病毒激发前状态（超几何检验：p=0.029）。这揭示了哮喘患者对环境刺激适应能力的丧失，并支持了哮喘中炎症和生理反应的生物学过程的不稳定性，促进了哮喘失控之一观点。
Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge.
Sinha A, Lutter R, Xu B4, Dekker T, Dierdorp B, Sterk PJ, Frey U, Eckert ED.
Abstract
Asthma is a dynamic disease, in which lung mechanical and inflammatory processes interact in a complex manner, often resulting in exaggerated physiological, in particular, inflammatory responses to exogenous triggers. We hypothesize that this may be explained by respiratory disease-related systems instability and loss of adaptability to changing environmental conditions, manifested in highly fluctuating biomarkers and symptoms. Using time series of inflammatory (eosinophils, neutrophils, FeNO), clinical and lung function biomarkers (PEF, FVC,FEV1), we estimated this loss of adaptive capacity (AC) during an experimental rhinovirus infection in 24 healthy and asthmatic human volunteers. Loss of AC was estimated by comparing similarities between pre- and post-challenge time series. Unlike healthy participants, the asthmatic's post-viral-challenge state resembled more other rhinovirus-infected asthmatics than their own pre-viral-challenge state (hypergeometric-test: p=0.029). This reveals loss of AC and supports the concept that in asthma, biological processes underlying inflammatory and physiological responses are unstable, contributing to loss of control.
哮喘是一种动态的疾病，肺内的机械和炎症过程以复杂的方式相互作用，常常导致过度的生理反应，特别是对外源性刺激的炎症反应。我们假设这可能是由于呼吸系统疾病相关的稳态失衡和对不断变化的环境条件的适应性丧失所致，表现为生物标志物和症状的高度波动。利用炎性（嗜酸性粒细胞、中性粒细胞、FeNO）、临床和肺功能生物标记物（PEF、FVC、FEV1）的时间序列，我们评估了24名健康和哮喘志愿者在实验性鼻病毒感染期间的适应能力是否丧失。通过比较激发前和激发后时间序列的相似性来评估适应能力是否受损。与健康受试者不同，哮喘患者的病毒激发后状态与其他鼻病毒感染的哮喘患者相似，但并非是其病毒激发前状态（超几何检验：p=0.029）。这揭示了哮喘患者对环境刺激适应能力的丧失，并支持了哮喘中炎症和生理反应的生物学过程的不稳定性，促进了哮喘失控之一观点。
(中日友好医院呼吸与危重症医学科 李红雯 摘译 林江涛 审校)
(Elife. 2019 Nov 5;8. pii: e47969. doi: 10.7554/eLife.47969.)
(Elife. 2019 Nov 5;8. pii: e47969. doi: 10.7554/eLife.47969.)
Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge.
Sinha A, Lutter R, Xu B4, Dekker T, Dierdorp B, Sterk PJ, Frey U, Eckert ED.
Abstract
Asthma is a dynamic disease, in which lung mechanical and inflammatory processes interact in a complex manner, often resulting in exaggerated physiological, in particular, inflammatory responses to exogenous triggers. We hypothesize that this may be explained by respiratory disease-related systems instability and loss of adaptability to changing environmental conditions, manifested in highly fluctuating biomarkers and symptoms. Using time series of inflammatory (eosinophils, neutrophils, FeNO), clinical and lung function biomarkers (PEF, FVC,FEV1), we estimated this loss of adaptive capacity (AC) during an experimental rhinovirus infection in 24 healthy and asthmatic human volunteers. Loss of AC was estimated by comparing similarities between pre- and post-challenge time series. Unlike healthy participants, the asthmatic's post-viral-challenge state resembled more other rhinovirus-infected asthmatics than their own pre-viral-challenge state (hypergeometric-test: p=0.029). This reveals loss of AC and supports the concept that in asthma, biological processes underlying inflammatory and physiological responses are unstable, contributing to loss of control.
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自然语言处理可促进基于EHR的过敏，哮喘和免疫学临床研究
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血液循环中MicroRNAs和T细胞因子的表达与哮喘发作的特点有关
