胃食管反流病与哮喘双向关联：利用一种国家样本队列进行的两项纵向随访研究
2019/12/09
摘要
背景：胃食管反流病（GERD）与哮喘之间具有相关性；然而，两者之间的因果关系暂不清楚。
目标：此研究的目的是描述GERD与哮喘之间的因果关系。
方法：入组人员来自2002年-2013年韩国国家健康保险服务-国家样本队列中年龄≥20岁的参与者。在研究I中，将116502名GERD患者以1：2的比例与23304名对照组患者进行匹配，并分析GERD患者中哮喘风险比。在研究II中，将104146名哮喘患者以1：1的比例与104146对照组患者进行配对，并分析哮喘患者中GERD风险比。使用分层COX比例模型。根据年龄和性别进行亚组分析。
结果：在研究I中，GERD组12.5% (14,595/116,502)合并哮喘，对照组7.8% (18,135/233,004)表现哮喘(P < 0.001)。GERD组哮喘风险比是对照I组的1.46倍(95% [CI] = 1.42-1.49, P < 0.001)。在研究II中，哮喘组16.9% (17,582/104,146)合并GERD，对照组中11.9%患有GERD。哮喘组发生GERD风险比时对照II组1.36倍(95% CI = 1.33-1.39, P < 0.001)。所有年龄和性别亚组结果一致。
结论;在研究人群中GERD与哮喘双向关联。
Bidirectional association between GERD and asthma: Two longitudinal follow-up studies using a national sample cohort.
Kim SY, Min C2, Oh DJ, Choi HG.
Abstract
BACKGROUND: A relation between gastroesophageal reflux disease (GERD) and asthma has been suggested; however, causality has not been investigated.
OBJECTIVE: This study aimed to delineate the causal relation between GERD and asthma.
METHODS: Participants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥ 20 years old were selected for this study. In study I, 116,502 GERD patients were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in GERD patients was analyzed. In study II, 104,146 asthma patients were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in asthma patients was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were performed according to age and sex.
RESULTS: In study I, 12.5% (14,595/116,502) of the GERD group and 7.8% (18,135/233,004) of the control I group presented asthma (P < 0.001). The GERD group demonstrated a 1.46-fold higher HR for asthma than the control I group (95% confidence interval [CI] = 1.42-1.49, P < 0.001). In study II, 16.9% (17,582/104,146) of the asthma group and 11.9% (12,393/104,146) of the control II group presented GERD (P < 0.001). The asthma group showed a 1.36-fold higher HR for GERD than the control II group (95% CI = 1.33-1.39, P < 0.001). All age and sex subgroups presented consistent results.
CONCLUSION: GERD and asthma had a bidirectional relation in the study population.
背景：胃食管反流病（GERD）与哮喘之间具有相关性；然而，两者之间的因果关系暂不清楚。
目标：此研究的目的是描述GERD与哮喘之间的因果关系。
方法：入组人员来自2002年-2013年韩国国家健康保险服务-国家样本队列中年龄≥20岁的参与者。在研究I中，将116502名GERD患者以1：2的比例与23304名对照组患者进行匹配，并分析GERD患者中哮喘风险比。在研究II中，将104146名哮喘患者以1：1的比例与104146对照组患者进行配对，并分析哮喘患者中GERD风险比。使用分层COX比例模型。根据年龄和性别进行亚组分析。
结果：在研究I中，GERD组12.5% (14,595/116,502)合并哮喘，对照组7.8% (18,135/233,004)表现哮喘(P < 0.001)。GERD组哮喘风险比是对照I组的1.46倍(95% [CI] = 1.42-1.49, P < 0.001)。在研究II中，哮喘组16.9% (17,582/104,146)合并GERD，对照组中11.9%患有GERD。哮喘组发生GERD风险比时对照II组1.36倍(95% CI = 1.33-1.39, P < 0.001)。所有年龄和性别亚组结果一致。
结论;在研究人群中GERD与哮喘双向关联。
（中日友好医院呼吸与危重症医学科一部 张鑫 摘译 林江涛 审校）
（J Allergy Clin Immunol Pract. 2019 Nov 13. pii: S2213-2198(19)30937-7）
（J Allergy Clin Immunol Pract. 2019 Nov 13. pii: S2213-2198(19)30937-7）
Bidirectional association between GERD and asthma: Two longitudinal follow-up studies using a national sample cohort.
Kim SY, Min C2, Oh DJ, Choi HG.
Abstract
BACKGROUND: A relation between gastroesophageal reflux disease (GERD) and asthma has been suggested; however, causality has not been investigated.
OBJECTIVE: This study aimed to delineate the causal relation between GERD and asthma.
METHODS: Participants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥ 20 years old were selected for this study. In study I, 116,502 GERD patients were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in GERD patients was analyzed. In study II, 104,146 asthma patients were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in asthma patients was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were performed according to age and sex.
RESULTS: In study I, 12.5% (14,595/116,502) of the GERD group and 7.8% (18,135/233,004) of the control I group presented asthma (P < 0.001). The GERD group demonstrated a 1.46-fold higher HR for asthma than the control I group (95% confidence interval [CI] = 1.42-1.49, P < 0.001). In study II, 16.9% (17,582/104,146) of the asthma group and 11.9% (12,393/104,146) of the control II group presented GERD (P < 0.001). The asthma group showed a 1.36-fold higher HR for GERD than the control II group (95% CI = 1.33-1.39, P < 0.001). All age and sex subgroups presented consistent results.
CONCLUSION: GERD and asthma had a bidirectional relation in the study population.
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英国成人哮喘患者急性发作模式：一项基于人群的研究
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奥玛珠单抗在治疗难治性哮喘和重症哮喘中的现实效果:比利时的一项国家队列研究
