阐明哮喘与肥胖之间的因果关系：双向孟德尔随机研究
2019/05/10
摘要
背景：哮喘和肥胖之间的观察性关联是存在的，但据此推断其因果关系仍受到质疑。我们利用公开的汇总统计数据，通过欧洲血统成人的孟德尔随机分析确定哮喘与肥胖之间的因果关系。
方法：我们使用公开的全基因组关联研究汇总统计进行了双样本双向孟德尔随机分析。应用固定效应荟萃分析，在每个方向上分析了哮喘和体质指数相关单核苷酸多态性的全基因组显著性。大量应用了敏感性分析。
结果：有证据支持体质指数对哮喘风险的因果关系增强[优势比1.18每单位增加，95％置信区间（CI）（1.11,1.25），P = 2×10-8]。未观察到哮喘对成人体重指数的显著因果关系[影响估计-0.004,95％CI（-0.018,0.009），P = 0.553]。
结论：我们的研究结果证实，在欧洲血统人群中，成人体质指数可能对哮喘风险有因果关系；而哮喘对体质指数的影响很小，即使存在这种影响。
Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.
Xu S, Gilliland FD, Conti DV.
Abstract
BACKGROUND:Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults.
METHODS:We performed two-sample bi-directional Mendelian randomization analysis using publicly available genome-wide association studies summary statistics. Single nucleotide polymorphisms associated with asthma and body mass index at genome-wide significance were combined using a fixed effect meta-analysis in each direction. An extensive sensitivity analysis was considered.
RESULTS:There was evidence in support of increasing causal effect of body mass index on risk of asthma (odds ratio 1.18 per unit increase, 95% confidence interval (CI) (1.11, 1.25), P = 2 × 10-8. No significant causal effect of asthma on adult body mass index was observed [estimate -0.004, 95% CI (-0.018, 0.009), P = 0.553].
CONCLUSIONS:Our results confirmed that in European-ancestry populations, adult body mass index is likely to be causally linked to the risk of asthma; yet the effect of asthma on body mass index is small, if present at all.
背景：哮喘和肥胖之间的观察性关联是存在的，但据此推断其因果关系仍受到质疑。我们利用公开的汇总统计数据，通过欧洲血统成人的孟德尔随机分析确定哮喘与肥胖之间的因果关系。
方法：我们使用公开的全基因组关联研究汇总统计进行了双样本双向孟德尔随机分析。应用固定效应荟萃分析，在每个方向上分析了哮喘和体质指数相关单核苷酸多态性的全基因组显著性。大量应用了敏感性分析。
结果：有证据支持体质指数对哮喘风险的因果关系增强[优势比1.18每单位增加，95％置信区间（CI）（1.11,1.25），P = 2×10-8]。未观察到哮喘对成人体重指数的显著因果关系[影响估计-0.004,95％CI（-0.018,0.009），P = 0.553]。
结论：我们的研究结果证实，在欧洲血统人群中，成人体质指数可能对哮喘风险有因果关系；而哮喘对体质指数的影响很小，即使存在这种影响。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Int J Epidemiol. 2019 Apr 21. pii: dyz070. doi: 10.1093/ije/dyz070.)
(Int J Epidemiol. 2019 Apr 21. pii: dyz070. doi: 10.1093/ije/dyz070.)
Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.
Xu S, Gilliland FD, Conti DV.
Abstract
BACKGROUND:Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults.
METHODS:We performed two-sample bi-directional Mendelian randomization analysis using publicly available genome-wide association studies summary statistics. Single nucleotide polymorphisms associated with asthma and body mass index at genome-wide significance were combined using a fixed effect meta-analysis in each direction. An extensive sensitivity analysis was considered.
RESULTS:There was evidence in support of increasing causal effect of body mass index on risk of asthma (odds ratio 1.18 per unit increase, 95% confidence interval (CI) (1.11, 1.25), P = 2 × 10-8. No significant causal effect of asthma on adult body mass index was observed [estimate -0.004, 95% CI (-0.018, 0.009), P = 0.553].
CONCLUSIONS:Our results confirmed that in European-ancestry populations, adult body mass index is likely to be causally linked to the risk of asthma; yet the effect of asthma on body mass index is small, if present at all.
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2008年至2016年瑞典西部哮喘患病率和呼吸系统症状的变化
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2000年和2010年美国邻近地区交通相关的空气污染和儿童哮喘负担
