环境超微粒子的时空变化与儿童哮喘发病率的关系
2019/03/21
摘要
原理：关于环境超细颗粒（<0.1μm）（UFPs）对儿童哮喘发展的影响知之甚少。
目的：检查产前和出生后早期接触UFPs与儿童哮喘发展之间的关系。
方法：2006年4月1日至2012年3月31日期间，加拿大多伦多市共有160,641例单胎活产从出生登记处确定。使用随机效应Cox比例风险模型评估暴露于环境空气污染物与儿童哮喘发病率（直至6岁）之间的关联，调整个人和邻居水平的协变量。我们研究了单一和多污染物模型，这些模型考虑了PM2.5和NO2的共同暴露。
检测和主要结果：我们在随访期间确定了27,062名患有哮喘发作的儿童。在调整后的模型中，妊娠中期接触UFPs（危险比（HR）/四分位数（IQR）增加= 1.09,95％CI：1.06-1.12）与哮喘发病率相关。在另外针对PM2.5和NO2调整的模型中，妊娠中期妊娠期UFP暴露与儿童哮喘发病率呈正相关（HR / IQR增加= 1.05,95％CI：1.01-1.09）。
结论：这是第一项评估围产期UFP暴露与儿童哮喘发病率之间关系的研究。在肺发育的关键时期暴露于UFP与儿童哮喘的发病有关，与PM2.5和NO2无关。
Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma.
Lavigne E, Donelle J, Hatzopoulou M, Van Ryswyk K, van Donkelaar A, Martin RV,Chen H, Stieb DM, Gasparrini A, Crighton E, Yasseen Iii AS, Burnett RT, Walker M, Weichenthal S.
Abstract
RATIONALE:Little is known regarding the impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood asthma development.
OBJECTIVE:To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma.
METHODS:A total of 160,641 singleton live births occurring in the City of Toronto, Canada between April 1st 2006 and March 31st 2012 were identified from a birth registry. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using random-effects Cox proportional hazards models, adjusting for personal- and neighborhood-level covariates. We investigated both single- and multi-pollutant models accounting for co-exposures to PM2.5 and NO2.
MEASUREMENTS AND MAIN RESULTS:We identified 27,062 children with incident asthma diagnosis during the follow-up. In adjusted models, second trimester exposure to UFPs (Hazard Ratio (HR) per interquartile (IQR) increase = 1.09, 95% CI: 1.06 - 1.12) was associated with asthma incidence. In models additionally adjusted for PM2.5 and NO2, UFPs exposure during the second trimester of pregnancy remained positively associated with childhood asthma incidence (HR per IQR increase = 1.05, 95% CI: 1.01 - 1.09).
CONCLUSIONS:This is the first study to evaluate the association between perinatal exposure to UFPs and the incidence of childhood asthma. Exposure to UFPs during a critical period of lung development was linked to the onset of asthma in children, independent of PM2.5 and NO2.
原理：关于环境超细颗粒（<0.1μm）（UFPs）对儿童哮喘发展的影响知之甚少。
目的：检查产前和出生后早期接触UFPs与儿童哮喘发展之间的关系。
方法：2006年4月1日至2012年3月31日期间，加拿大多伦多市共有160,641例单胎活产从出生登记处确定。使用随机效应Cox比例风险模型评估暴露于环境空气污染物与儿童哮喘发病率（直至6岁）之间的关联，调整个人和邻居水平的协变量。我们研究了单一和多污染物模型，这些模型考虑了PM2.5和NO2的共同暴露。
检测和主要结果：我们在随访期间确定了27,062名患有哮喘发作的儿童。在调整后的模型中，妊娠中期接触UFPs（危险比（HR）/四分位数（IQR）增加= 1.09,95％CI：1.06-1.12）与哮喘发病率相关。在另外针对PM2.5和NO2调整的模型中，妊娠中期妊娠期UFP暴露与儿童哮喘发病率呈正相关（HR / IQR增加= 1.05,95％CI：1.01-1.09）。
结论：这是第一项评估围产期UFP暴露与儿童哮喘发病率之间关系的研究。在肺发育的关键时期暴露于UFP与儿童哮喘的发病有关，与PM2.5和NO2无关。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Am J Respir Crit Care Med. 2019 Feb 20. doi: 10.1164/rccm.201810-1976OC.)
(Am J Respir Crit Care Med. 2019 Feb 20. doi: 10.1164/rccm.201810-1976OC.)
Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma.
Lavigne E, Donelle J, Hatzopoulou M, Van Ryswyk K, van Donkelaar A, Martin RV,Chen H, Stieb DM, Gasparrini A, Crighton E, Yasseen Iii AS, Burnett RT, Walker M, Weichenthal S.
Abstract
RATIONALE:Little is known regarding the impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood asthma development.
OBJECTIVE:To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma.
METHODS:A total of 160,641 singleton live births occurring in the City of Toronto, Canada between April 1st 2006 and March 31st 2012 were identified from a birth registry. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using random-effects Cox proportional hazards models, adjusting for personal- and neighborhood-level covariates. We investigated both single- and multi-pollutant models accounting for co-exposures to PM2.5 and NO2.
MEASUREMENTS AND MAIN RESULTS:We identified 27,062 children with incident asthma diagnosis during the follow-up. In adjusted models, second trimester exposure to UFPs (Hazard Ratio (HR) per interquartile (IQR) increase = 1.09, 95% CI: 1.06 - 1.12) was associated with asthma incidence. In models additionally adjusted for PM2.5 and NO2, UFPs exposure during the second trimester of pregnancy remained positively associated with childhood asthma incidence (HR per IQR increase = 1.05, 95% CI: 1.01 - 1.09).
CONCLUSIONS:This is the first study to evaluate the association between perinatal exposure to UFPs and the incidence of childhood asthma. Exposure to UFPs during a critical period of lung development was linked to the onset of asthma in children, independent of PM2.5 and NO2.
上一篇：
英国当前哮喘患病率和吸入性皮质类固醇治疗的变化：基于人群2006-2016的队列
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过敏和哮喘疾病发展中的环境暴露的作用及其机制
