高音调呼吸音在哮喘患儿中的临床应用
2018/09/10
摘要
目的：呼吸音参数评估哮喘患者气道状况的新标志物。我们研究了新的呼吸音参数以明确其评估哮喘儿童的效用。
方法：本研究包括57位儿童 (6-16 岁，平均年龄为9.0 岁)。在β2激动剂吸入前后分别测量新的呼吸音参数——曲线下面积 (AUC) > 1000 Hz (A1000 [dBm·hz]) ,和在100赫兹到最高频率的功率谱之间A1000与总的曲线下面积的比值(A1000/AT [%])。呼吸描记法和强迫振荡技术作为评价方法。
结果：A1000 的值与 FEV1 呈负相关 (p = 0.028)。ΔFEV1 的增加与ΔA1000 的减少相关 (p = 0.001) 和ΔA1000/AT 的减少(p = 0.036)。
结论：A1000 可以用于评估气道状况, ΔA1000 和ΔA1000/AT可用于描述气管扩张度。这些参数对哮喘患儿支气管可逆性的评估有参考价值。
Clinical Application of High-pitched Breath Sound in Children with Asthma.
Kondo Y, Nukaga M, Enseki M, Tabata H, Hirai K, Kato M, Mochizuki H.
Abstract
OBJECTIVE:Breath sound parameters have been suggested to be a new biomarker of airway conditions in asthmatic patients. We investigated new breath sound parameters to determine their utility for evaluating asthmatic children.
METHODS:Fifty-seven children (mean age, 9.0 years, 6-16 years) were included in the present study. The new breath sound parameters, the area under the curve (AUC)>1,000 Hz (A1000 [dBm·Hz]) and the ratio of the A1000 to the total AUC at 100 Hz to the highest frequency of the dBm power spectrum (AT) (A1000/AT [%]) were measured before and after β2 agonist inhalation. Spirography and the forced oscillation technique were also used to evaluate all subjects.
RESULTS:The value of A1000 was negatively correlated with the FEV1 (p=0.028). The increase in the ΔFEV1 was correlated with the decrease in the ΔA1000 (p=0.001) and the ΔA1000/AT (p=0.036).
CONCLUSIONS:The A1000 indicates the airway condition, and the ΔA1000 and the ΔA1000/AT well describe the dilatation of the airways. These parameters are useful for the assessment of bronchial reversibility in asthmatic children.
目的：呼吸音参数评估哮喘患者气道状况的新标志物。我们研究了新的呼吸音参数以明确其评估哮喘儿童的效用。
方法：本研究包括57位儿童 (6-16 岁，平均年龄为9.0 岁)。在β2激动剂吸入前后分别测量新的呼吸音参数——曲线下面积 (AUC) > 1000 Hz (A1000 [dBm·hz]) ,和在100赫兹到最高频率的功率谱之间A1000与总的曲线下面积的比值(A1000/AT [%])。呼吸描记法和强迫振荡技术作为评价方法。
结果：A1000 的值与 FEV1 呈负相关 (p = 0.028)。ΔFEV1 的增加与ΔA1000 的减少相关 (p = 0.001) 和ΔA1000/AT 的减少(p = 0.036)。
结论：A1000 可以用于评估气道状况, ΔA1000 和ΔA1000/AT可用于描述气管扩张度。这些参数对哮喘患儿支气管可逆性的评估有参考价值。
(中日友好医院呼吸与危重症医学科 禹汶伯 摘译 林江涛 审校)
(Tokai J Exp Clin Med. 2018 Jul 20;43(2):74-80.)
(Tokai J Exp Clin Med. 2018 Jul 20;43(2):74-80.)
Clinical Application of High-pitched Breath Sound in Children with Asthma.
Kondo Y, Nukaga M, Enseki M, Tabata H, Hirai K, Kato M, Mochizuki H.
Abstract
OBJECTIVE:Breath sound parameters have been suggested to be a new biomarker of airway conditions in asthmatic patients. We investigated new breath sound parameters to determine their utility for evaluating asthmatic children.
METHODS:Fifty-seven children (mean age, 9.0 years, 6-16 years) were included in the present study. The new breath sound parameters, the area under the curve (AUC)>1,000 Hz (A1000 [dBm·Hz]) and the ratio of the A1000 to the total AUC at 100 Hz to the highest frequency of the dBm power spectrum (AT) (A1000/AT [%]) were measured before and after β2 agonist inhalation. Spirography and the forced oscillation technique were also used to evaluate all subjects.
RESULTS:The value of A1000 was negatively correlated with the FEV1 (p=0.028). The increase in the ΔFEV1 was correlated with the decrease in the ΔA1000 (p=0.001) and the ΔA1000/AT (p=0.036).
CONCLUSIONS:The A1000 indicates the airway condition, and the ΔA1000 and the ΔA1000/AT well describe the dilatation of the airways. These parameters are useful for the assessment of bronchial reversibility in asthmatic children.
上一篇：
过敏性疾病和哮喘生物标志物的最新进展和亮点
下一篇：
治疗哮喘和慢性阻塞性肺疾病的靶向细胞因子
