过敏性疾病的细胞因子靶向生物学治疗
2018/05/03
摘要
目的：哮喘和过敏性疾病患病率的持续上升，加重了卫生保健系统的经济负担，并降低了这些患者的生活质量。许多内在的和外在的因素参与了过敏反应的发生及持续过程。细胞因子是细胞生长、分化、活化行为中参与调控与介导免疫应答过程的蛋白。
数据来源/研究选择：我们在clinicaltrials.gov网站上检索了相关的临床试验，并在PubMed检索了近期的相关研究。
结果与结论：本篇综述聚焦于参与过敏反应的细胞因子的研究，尤其是那些在研或已用于治疗的细胞因子。
Cytokine-targeting biologics for allergic diseases.
Monica G. Lawrence, et al.
Abstract
OBJECTIVE：Asthma and allergic diseases continue to increase in prevalence, creating a financial burden on the health care system and impacting the quality of life for those who suffer from these diseases. Many intrinsic and extrinsic factors are involved in the initiation and maintenance of the allergic response. Cytokines are proteins with growth, differentiation, and activation functions that regulate and direct the nature of immune responses.
DATA SOURCES/STUDY SELECTIONS：We searched clinicaltrials.gov for relevant clinical trials. PubMed search was performed for recent appropriate studies.
RESULTS AND CONCLUSIONS：This review focused on cytokines involved in the allergic response with an emphasis on those for which therapies are being or have been developed.
目的：哮喘和过敏性疾病患病率的持续上升，加重了卫生保健系统的经济负担，并降低了这些患者的生活质量。许多内在的和外在的因素参与了过敏反应的发生及持续过程。细胞因子是细胞生长、分化、活化行为中参与调控与介导免疫应答过程的蛋白。
数据来源/研究选择：我们在clinicaltrials.gov网站上检索了相关的临床试验，并在PubMed检索了近期的相关研究。
结果与结论：本篇综述聚焦于参与过敏反应的细胞因子的研究，尤其是那些在研或已用于治疗的细胞因子。
（复旦大学附属中山医院 呼吸内科 罗锦龙 摘译 杨冬 审校）
（Ann Allergy Asthma Immunol, 2018 Feb）
（Ann Allergy Asthma Immunol, 2018 Feb）
Cytokine-targeting biologics for allergic diseases.
Monica G. Lawrence, et al.
Abstract
OBJECTIVE：Asthma and allergic diseases continue to increase in prevalence, creating a financial burden on the health care system and impacting the quality of life for those who suffer from these diseases. Many intrinsic and extrinsic factors are involved in the initiation and maintenance of the allergic response. Cytokines are proteins with growth, differentiation, and activation functions that regulate and direct the nature of immune responses.
DATA SOURCES/STUDY SELECTIONS：We searched clinicaltrials.gov for relevant clinical trials. PubMed search was performed for recent appropriate studies.
RESULTS AND CONCLUSIONS：This review focused on cytokines involved in the allergic response with an emphasis on those for which therapies are being or have been developed.
