哮喘联盟

   摘要
   背景：健康既往吸烟者肺功能情况相关研究较少。本研究旨在评价没有任何肺部基础疾病既往的吸烟习惯对肺功能造成的影响。
   方法：将在农村医疗卫生机构就诊的无肺部基础疾病的患者纳入研究。所有受试者接受问卷调查，其中包括吸烟史。就受试者FVC和FEV1进行测定。
   结果：总计分析802名受试者（364名男性和438名女性）。当前吸烟者和既往吸烟者zFEV1（统计得到FEV1综合z评分）低于未吸烟者。大于30包·年的既往吸烟者平均zFEV1低于吸烟史较短的既往吸烟者。单因素分析提示包·年与既往吸烟者和当前吸烟者zFEV1水平呈负相关。而既往吸烟者戒烟时长与zFEV1无显著相关。
   结论：研究数据表明既往吸烟的健康人群肺功能下降与吸烟量相关。即使长时间戒烟，已经受损的肺功能很难恢复原有水平。
 

（上海交通大学医学院附属瑞金医院呼吸与危重症医学科 周剑平 万欢英 摘译）
（Respir Investig. 2018 Jan;56(1):21-27. doi: 10.1016/j.resinv.2017.09.005. Epub 2017 Oct 27. ）

Respiratory function in healthy ever-smokers is impaired by smoking habits in a dose-dependent manner.
 

Osanai S et al.
 

Abstract

BACKGROUND:There is limited information about the respiratory function of ever-smokers without lung disorders. We sought to assess the effects of smoking habits on respiratory function in subjects without lung disorders.

METHODS:Subjects were recruited from among patients without any evidence of respiratory disorders who visited rural primary care clinics. Each participant was asked to answer a questionnaire that included questions smoking history. Their forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured.

RESULTS:We analyzed 802 subjects (364 men and 438 women). The means of the lambda-mu-sigma method derived z-score of FEV1 (zFEV1) both in current-smokers and ex-smokers were lower than that in never-smokers. The mean zFEV1 in the ever-smokers with more than 30 pack-years of smoking history were lower than that in the ever-smokers with less smoking history. Univariate analysis showed that there were significant negative correlations between pack-years and zFEV1 both in the ex-smokers and current-smokers. There was no significant correlation between the duration of smoking cessation and zFEV1 in the ex-smokers.

CONCLUSIONS:Our data suggests that respiratory function in healthy ever-smokers is decreased based on smoking habits in a dose-dependent manner. Even after a long period of smoking cessation, the decreased respiratory function seems to be maintained in ex-smokers.