哮喘联盟

   摘要

   背景：吸烟是一个显著的公共卫生问题。然而，现行的治疗方法并不能充分降低吸烟率。本研究旨在评价患者对于肺功能数据中“肺功能-肺-年龄”预测值对于戒烟的促进作用。
   方法：从2010年12月至2011年9月，受试者前瞻性地进入标准化戒烟流程（12周内完成第1次至5次随访）并单盲进入SLA组或对照组。SLA组受试者被告知其通过肺功能预测的肺年龄并告知与实际年龄的差距，而对照组受试者则不知情。首要研究终点为第5次随访的戒断率，而次要研究终点为1年后持续戒断患者比例。
   结果：126名日本烟民（88名男性）参与被随机分入SLA组（n=52）或对照组（n=74）。第5次随访戒断率两组相似（SLA组 59.6% vs 对照组 41.9%；P=0.07）。然而，一年后持续戒断率两组也相似（SLA组 78.6% vs 对照组 69%；P=0.5497）。调整基线人群特征后多因素回归分析提示告知患者SLA，伐尼克兰的使用以及年龄等因素均与第5次随访戒断率有关，而仅年龄因素与一年后持续戒断率有关。
   结论: 告知患者SLA可以有效促进日本烟民戒烟，尽管药物和年龄也同时可以影响戒烟。

 

（上海交通大学医学院附属瑞金医院呼吸与危重症医学科 周剑平 万欢英 摘译）

（J Thorac Dis. 2017 Dec;9(12):5052-5060. doi: 10.21037/jtd.2017.11.06.）

Effect of telling patients their "spirometric-lung-age" on smoking cessation in Japanese smokers.

 J Thorac Dis. 2017 Dec;9(12):5052-5060. doi: 10.21037/jtd.2017.11.06.

Takagi H et al.
 
Abstract
BACKGROUND:Cigarette smoking remains a significant public health problem. However, current treatment programs have not yet succeeded in sufficiently reducing smoking rates. The study aimed to examine whether patients' recognition of "spirometric-lung-age (SLA)" estimated from spirometry data prompts smoking cessation.
METHODS:From December 2010 to September 2011, participating smokers were prospectively enrolled into the standardized smoking cessation program (Visits 1-5 for 12 weeks) and assigned single-blindly to either SLA assessment or control groups. The SLA group was informed of the estimated age of their lungs from spirometry analysis and given an opportunity to recognize the difference from their actual chronological age, whereas the control group was not. The primary calculation of outcome was the smoking quit rate on Visit 5, whereas the secondary end-point was the proportion of patients who remained abstinent 1 year later.
RESULTS:One hundred and twenty-six Japanese smokers (88 males) participated and were randomly assigned to the SLA group (n=52) or the control group (n=74). The smoking quit rate on Visit 5 was similar in the SLA assessment group and control group (59.6% vs. 41.9%; P=0.0700). However, the proportion of patients who remained abstinent 1 year later was similar in both groups (78.6% vs. 69.0%; P=0.5497). Multivariate logistic regression analysis after adjusting baseline characteristics demonstrated that telling patients their SLA, the use of varenicline, and age were significantly associated with smoking quit rate on Visit 5 whereas only age was associated with remaining abstinent 1 year later.
CONCLUSIONS:Telling patients their SLA can become a useful tool prompting smoking cessation among Japanese smokers although other factors such as pharmacotherapy and age also influence the cessation of smoking.