烟草依赖者电子烟治疗：探索性研究
2018/01/15
摘要
背景：电子烟（EC）已经成为吸烟者降低烟害的替代方法。然而，ECs能否作为治疗方法尚不明确。这一探索性研究针对主动戒烟者进行标准戒烟治疗，选择含尼古丁或不含尼古丁EC按需应用观察对戒烟的疗效。
方法：主动戒烟者接受为期8周的标准戒烟治疗，给予尼古丁透皮贴，行为咨询以及按需应用含尼古丁或不含尼古丁EC。期间吸烟和EC使用情况均予以记录，直至第24周。
结果：40名受试者纳入研究。在第24周，6名（15%）受试者彻底戒断，而每天烟量减少约为6.8±12。而使用含尼古丁或不含尼古丁EC两组之间吸烟情况并无差异（24周戒断比例：含尼古丁EC组=4/20（20%）；不含尼古丁EC组=2/20（10%）;p=0.66）。在随访中，62.5%受试者未使用EC。
结论：将第2代电子烟加入门诊戒烟治疗可行。在戒烟者中，半数在6个月随访中仍应用EC。不同吸烟者对于EC需求各不相同，而已经戒断者则喜欢更换为低尼古丁浓度的EC。需要进一步研究评价ECs是否能够减轻烟害，并作为现有戒烟策略的有效补充。
Electronic cigarettes for adults with tobacco dependence enrolled in a tobacco treatment program: A pilot study.
Addict Behav. 2017 Nov 28;80:1-5. doi: 10.1016/j.addbeh.2017.11.033. [Epub ahead of print]
Baldassarri SR, Bernstein SL, Chupp GL, Slade MD, Fucito LM, Toll BA6.
Abstract
INTRODUCTION:Electronic cigarettes (ECs) have emerged as a potential harm-reducing alternative for tobacco smokers. However, the role ECs might play in treatment settings is unclear. We conducted an exploratory study of treatment-seeking smokers enrolling in a standard tobacco treatment program who were provided with either a nicotine or non-nicotine EC to use as needed to cease tobacco smoking.
METHODS:Treatment-seeking smokers received standard tobacco treatment for 8weeks and were given nicotine transdermal patch therapy, behavioral counseling, and either a nicotine or non-nicotine EC to use as needed. Smoking and EC use patterns were tracked longitudinally to week 24.
RESULTS:40 subjects were enrolled into the study. At week 24, 6 subjects (15%) were abstinent, and the mean reduction in reported cigarettes smoked per day was 6.8±12. There were no significant differences in smoking outcomes between those who received a nicotine or non-nicotine EC (proportion abstinent at 24weeks: nicotine EC=4/20 (20%); non-nicotine EC=2/20 (10%); p=0.66). Among subjects assessed at follow-up, 62.5% were EC non-users.
CONCLUSIONS:The addition of a 2nd generation EC to outpatient tobacco treatment among tobacco smokers is feasible. Among those who quit smoking, half were still using the EC at 6-month follow-up. Appeal of the EC among smokers was variable, and those who had quit smoking tended to switch to lower strength nicotine solutions. Further research is needed to determine whether ECs can reduce harm and be an effective adjunct to existing tobacco treatment interventions.
背景：电子烟（EC）已经成为吸烟者降低烟害的替代方法。然而，ECs能否作为治疗方法尚不明确。这一探索性研究针对主动戒烟者进行标准戒烟治疗，选择含尼古丁或不含尼古丁EC按需应用观察对戒烟的疗效。
方法：主动戒烟者接受为期8周的标准戒烟治疗，给予尼古丁透皮贴，行为咨询以及按需应用含尼古丁或不含尼古丁EC。期间吸烟和EC使用情况均予以记录，直至第24周。
结果：40名受试者纳入研究。在第24周，6名（15%）受试者彻底戒断，而每天烟量减少约为6.8±12。而使用含尼古丁或不含尼古丁EC两组之间吸烟情况并无差异（24周戒断比例：含尼古丁EC组=4/20（20%）；不含尼古丁EC组=2/20（10%）;p=0.66）。在随访中，62.5%受试者未使用EC。
结论：将第2代电子烟加入门诊戒烟治疗可行。在戒烟者中，半数在6个月随访中仍应用EC。不同吸烟者对于EC需求各不相同，而已经戒断者则喜欢更换为低尼古丁浓度的EC。需要进一步研究评价ECs是否能够减轻烟害，并作为现有戒烟策略的有效补充。
（上海交通大学医学院附属瑞金医院呼吸与危重症医学科 周剑平 万欢英 摘译）
（Addict Behav. 2017 Nov 28;80:1-5. doi: 10.1016/j.addbeh.2017.11.033. [Epub ahead of print]）
（Addict Behav. 2017 Nov 28;80:1-5. doi: 10.1016/j.addbeh.2017.11.033. [Epub ahead of print]）
Electronic cigarettes for adults with tobacco dependence enrolled in a tobacco treatment program: A pilot study.
Addict Behav. 2017 Nov 28;80:1-5. doi: 10.1016/j.addbeh.2017.11.033. [Epub ahead of print]
Baldassarri SR, Bernstein SL, Chupp GL, Slade MD, Fucito LM, Toll BA6.
Abstract
INTRODUCTION:Electronic cigarettes (ECs) have emerged as a potential harm-reducing alternative for tobacco smokers. However, the role ECs might play in treatment settings is unclear. We conducted an exploratory study of treatment-seeking smokers enrolling in a standard tobacco treatment program who were provided with either a nicotine or non-nicotine EC to use as needed to cease tobacco smoking.
METHODS:Treatment-seeking smokers received standard tobacco treatment for 8weeks and were given nicotine transdermal patch therapy, behavioral counseling, and either a nicotine or non-nicotine EC to use as needed. Smoking and EC use patterns were tracked longitudinally to week 24.
RESULTS:40 subjects were enrolled into the study. At week 24, 6 subjects (15%) were abstinent, and the mean reduction in reported cigarettes smoked per day was 6.8±12. There were no significant differences in smoking outcomes between those who received a nicotine or non-nicotine EC (proportion abstinent at 24weeks: nicotine EC=4/20 (20%); non-nicotine EC=2/20 (10%); p=0.66). Among subjects assessed at follow-up, 62.5% were EC non-users.
CONCLUSIONS:The addition of a 2nd generation EC to outpatient tobacco treatment among tobacco smokers is feasible. Among those who quit smoking, half were still using the EC at 6-month follow-up. Appeal of the EC among smokers was variable, and those who had quit smoking tended to switch to lower strength nicotine solutions. Further research is needed to determine whether ECs can reduce harm and be an effective adjunct to existing tobacco treatment interventions.
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电子烟安全性评估及其与心血管疾病的关系
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伐尼克兰和尼古丁替代治疗在老年和青年吸烟者戒烟过程中的疗效比较： 一项台湾前瞻性队列研究
