年龄与哮喘表型有关
2017/07/12
摘要
背景和目的：年龄与哮喘表型之间的关系是重要的，随着人口老龄化，哮喘在老年人群中越来越常见，且目前的哮喘治疗方法是以哮喘表型为指导的。本研究旨在评估年龄是否与特定哮喘表型相关。
方法：这是一项横断面研究。我们收集了不同程度的哮喘患者。受试者进行了肺功能检测，过敏原皮肤点刺试验，回答哮喘控制问卷和采集血样。我们通过二元逻辑回归分析来评估年龄是否与哮喘表型相关。
结果：我们招收了868名受试者入组。与40岁以下受试者相比，年龄较大的受试者不可逆气流堵塞和重症哮喘发生几率较高，其中41岁-64岁受试者不可逆气流堵塞OR1.83（95%CI:2.15-3.63），重症哮喘OR3.23(95%CI:2.12–5.60)；65岁以上受试者OR3.45（95%CI:2.12–5.60），重症哮喘OR4.55(95% CI: 2.39 -8.67)。而过敏性哮喘和嗜酸细胞相关性哮喘的发生几率较低，其中41岁-64岁受试者OR0.56（95%CI:0.39-0.79），65岁以上受试者OR0.39（95%CI:0.24–0.64）。
结论：本研究结果表明，年龄较大的哮喘患者过敏性哮喘和嗜酸细胞相关性哮喘的发生几率较低，而不可逆气道阻塞和重症哮喘的发生几率较高。
Age is associated with asthma phenotypes
Ponte EV1, Lima A2, Almeida PCA2, de Jesus JPV2, Lima VB2, Sichilone N3, Souza-Machado A4, Cruz ÁA4
Abstract
BACKGROUND AND OBJECTIVE:The relationship between age and asthma phenotypes is important as population is ageing, asthma is becoming common in older ages and recently developed treatments for asthma are guided by phenotypes. The aim of this study is to evaluate whether age is associated with specific asthma phenotypes.
METHODS:This is a cross-sectional study. We included subjects with asthma of varied degrees of severity. Subjects underwent spirometry, skin prick test to aeroallergens, answered the Asthma Control Questionnaire and had blood samples collected. We performed binary logistic regression analysis to evaluate whether age is associated with asthma phenotypes.
RESULTS:We enrolled 868 subjects. In comparison with subjects ≤ 40 years, older subjects had high odds of irreversible airway obstruction (from 41 to 64 years, OR: 1.83 (95% CI: 1.32-2.54); ≥65 years, OR: 3.45 (2.12-5.60)) and severe asthma phenotypes (from 41 to 64 years, OR: 3.23 (2.26-4.62); ≥65 years, OR: 4.55 (2.39-8.67)). Older subjects had low odds of atopic (from 41 to 64 years, OR: 0.56 (0.39-0.79); ≥65 years, OR: 0.47 (0.27-0.84)) and eosinophilic phenotypes (from 41 to 64 years, OR: 0.63 (0.46-0.84); ≥65 years, OR: 0.39 (0.24-0.64)).
CONCLUSION:Older subjects with asthma have low odds of atopic and eosinophilic phenotypes, whereas they present high odds of irreversible airway obstruction and severe asthma.
背景和目的：年龄与哮喘表型之间的关系是重要的，随着人口老龄化，哮喘在老年人群中越来越常见，且目前的哮喘治疗方法是以哮喘表型为指导的。本研究旨在评估年龄是否与特定哮喘表型相关。
方法：这是一项横断面研究。我们收集了不同程度的哮喘患者。受试者进行了肺功能检测，过敏原皮肤点刺试验，回答哮喘控制问卷和采集血样。我们通过二元逻辑回归分析来评估年龄是否与哮喘表型相关。
结果：我们招收了868名受试者入组。与40岁以下受试者相比，年龄较大的受试者不可逆气流堵塞和重症哮喘发生几率较高，其中41岁-64岁受试者不可逆气流堵塞OR1.83（95%CI:2.15-3.63），重症哮喘OR3.23(95%CI:2.12–5.60)；65岁以上受试者OR3.45（95%CI:2.12–5.60），重症哮喘OR4.55(95% CI: 2.39 -8.67)。而过敏性哮喘和嗜酸细胞相关性哮喘的发生几率较低，其中41岁-64岁受试者OR0.56（95%CI:0.39-0.79），65岁以上受试者OR0.39（95%CI:0.24–0.64）。
结论：本研究结果表明，年龄较大的哮喘患者过敏性哮喘和嗜酸细胞相关性哮喘的发生几率较低，而不可逆气道阻塞和重症哮喘的发生几率较高。
(中日友好医院医院呼吸与危重症医学科王瑞茵摘译 林江涛审校)
（Respirology. 2017 Jun 27. doi: 10.1111/resp.13102.）
（Respirology. 2017 Jun 27. doi: 10.1111/resp.13102.）
Age is associated with asthma phenotypes
Ponte EV1, Lima A2, Almeida PCA2, de Jesus JPV2, Lima VB2, Sichilone N3, Souza-Machado A4, Cruz ÁA4
Abstract
BACKGROUND AND OBJECTIVE:The relationship between age and asthma phenotypes is important as population is ageing, asthma is becoming common in older ages and recently developed treatments for asthma are guided by phenotypes. The aim of this study is to evaluate whether age is associated with specific asthma phenotypes.
METHODS:This is a cross-sectional study. We included subjects with asthma of varied degrees of severity. Subjects underwent spirometry, skin prick test to aeroallergens, answered the Asthma Control Questionnaire and had blood samples collected. We performed binary logistic regression analysis to evaluate whether age is associated with asthma phenotypes.
RESULTS:We enrolled 868 subjects. In comparison with subjects ≤ 40 years, older subjects had high odds of irreversible airway obstruction (from 41 to 64 years, OR: 1.83 (95% CI: 1.32-2.54); ≥65 years, OR: 3.45 (2.12-5.60)) and severe asthma phenotypes (from 41 to 64 years, OR: 3.23 (2.26-4.62); ≥65 years, OR: 4.55 (2.39-8.67)). Older subjects had low odds of atopic (from 41 to 64 years, OR: 0.56 (0.39-0.79); ≥65 years, OR: 0.47 (0.27-0.84)) and eosinophilic phenotypes (from 41 to 64 years, OR: 0.63 (0.46-0.84); ≥65 years, OR: 0.39 (0.24-0.64)).
CONCLUSION:Older subjects with asthma have low odds of atopic and eosinophilic phenotypes, whereas they present high odds of irreversible airway obstruction and severe asthma.
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哮喘成人中的合并症：基于苏格兰140万成人群体的横断面研究
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家庭的兄弟姐妹与婴儿鼻腔和粪便菌群的关系
