在美国的孩子中，哮喘、花粉症和食物过敏与护理人员报告的言语障碍有关
2016/11/09
摘要
背景：患有哮喘、花粉症和食物过敏的孩子可能有多个因素能增加他们的言语障碍的风险，包括过敏性炎症，注意缺陷障碍/注意缺陷多动障碍，睡眠障碍。然而，很少有研究探讨哮喘、过敏性疾病、言语障碍之间的关系。我们试图确定是否哮喘、花粉症和食物过敏与儿童的言语障碍有关联，疾病的严重程度、睡眠障碍、或注意缺陷障碍/注意缺陷多动障碍能否对这些关联有影响。
方法：对来自美国19个群体的337285名年龄在2-17岁的儿童进行了横截面研究，包括1997至2013年国民健康访问调查和2003 / 4和2007 / 8届全国儿童健康调查。
结果：在多变量模型中，控制年龄、人口因素、医疗保健，和湿疹史，哮喘史（OR值1.18，95%可信区间：1.04~1.34，P = 0.01），一年的花粉热史（1.44，[ 1.28-1.62 ]，P＜0.0001）和食物过敏（1.35 [ 1.13-1.62 ]，P = 0.001）与言语障碍的风险增加相关。当前患有哮喘（1.37 [ 1.15-1.59 ]，P = 0.0003）而不是过去患有哮喘（P = 0.06）的儿童言语障碍的风险增加。在一项评估护理人员报告的哮喘严重程度的研究中，轻度（1.58 [ 1.20-2.08 ]，P = 0.001）和中度（2.99 [ 1.54-3.41 ]，P＜0.0001）哮喘患者言语障碍的风险增加相关；然而，严重哮喘与言语障碍几率最高相关（5.70 [ 2.36-13.78 ]，P = 0.0001）。
结论：儿童哮喘、花粉症和食物过敏与言语障碍的风险增加有关。描述这些相互关系的未来的前瞻性研究是必要的。
关键词：ADD/ADHD；过敏；哮喘；特应性疾病；食物过敏；花粉热；睡眠障碍；学语迟缓；言语障碍
（杨冬 审校）
Pediatr Allergy Immunol. 2016 Sep;27(6):604-11. doi: 10.1111/pai.12580. Epub 2016 May 27.
Asthma, hay fever, and food allergy are associated with caregiver-reported speech disorders in US children.
Strom MA1, Silverberg JI2,3.
Author information
Abstract
BACKGROUND:Children with asthma, hay fever, and food allergy may have several factors that increase their risk of speech disorder, including allergic inflammation, ADD/ADHD, and sleep disturbance. However, few studies have examined a relationship between asthma, allergic disease, and speech disorder. We sought to determine whether asthma, hay fever, and food allergy are associated with speech disorder in children and whether disease severity, sleep disturbance, or ADD/ADHD modified such associations.
METHODS:We analyzed cross-sectional data on 337,285 children aged 2-17 years from 19 US population-based studies, including the 1997-2013 National Health Interview Survey and the 2003/4 and 2007/8 National Survey of Children's Health.
RESULTS:In multivariate models, controlling for age, demographic factors, healthcare utilization, and history of eczema, lifetime history of asthma(odds ratio [95% confidence interval]: 1.18 [1.04-1.34], p = 0.01), and one-year history of hay fever (1.44 [1.28-1.62], p < 0.0001) and food allergy (1.35 [1.13-1.62], p = 0.001) were associated with increased odds of speech disorder. Children with current (1.37 [1.15-1.59] p = 0.0003) but not past (p = 0.06) asthma had increased risk of speech disorder. In one study that assessed caregiver-reported asthma severity, mild (1.58 [1.20-2.08], p = 0.001) and moderate (2.99 [1.54-3.41], p < 0.0001) asthma were associated with increased odds of speech disorder; however, severeasthma was associated with the highest odds of speech disorder (5.70 [2.36-13.78], p = 0.0001).
CONCLUSION:Childhood asthma, hay fever, and food allergy are associated with increased risk of speech disorder. Future prospective studies are needed to characterize the associations.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:ADD/ADHD; allergy; asthma; atopic disease; food allergy; hay fever; sleep disturbance; speech delay; speech disorder
Pediatr Allergy Immunol. 2016 Sep;27(6):604-11. doi: 10.1111/pai.12580. Epub 2016 May 27.
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