使用漂白剂进行家庭清洁的妇女患非过敏性哮喘的风险增加
2016/10/09
摘要
背景：漂白剂被广泛用于家庭清洁。虽然公认漂白剂的职业使用可能对呼吸系统有不利的影响，但它作为家庭使用是否会成为哮喘的一个危险因素还未为可知。
目的：评估家用漂白剂在家庭清洁中的使用是否与哮喘和其他呼吸道疾病有关。
方法：对参与随访的哮喘遗传和环境流行病学研究（EGEA）的607位女性进行问卷调查，获得其呼吸道症状、清洁习惯，和一些数据（皮肤点刺试验、支气管激发试验和白细胞），并对这些信息进行分析。漂白剂使用的评估分为3类（< 1天/周；1-3天/周；4-7天/周“频繁”）。
结果：总体而言，37%的妇女每周都使用漂白剂。频繁使用漂白剂的女性（11%）与不使用者相比较更可能当前有哮喘（调整后的比值比（aOR）= 1.7；95%可信区间（95% CI）为1.0-3.0）。在患有哮喘的妇女中，频繁使用漂白剂的与较高的血液中性粒细胞计数显着相关。漂白剂的使用与非过敏性哮喘显著相关（aOR 3.3；95% CI 1.5-7.1），尤其是与非过敏性成人型哮喘（aOR 4.9；95% CI 2.0-11.6）显著相关。一致的是，没有过敏性致敏的妇女使用漂白剂与支气管高反应性、哮喘样症状、慢性咳嗽呈显著正相关性。过敏性哮喘没有观察到相关性。
结论：频繁使用漂白剂用于家庭清洁与女性非过敏性的成人哮喘发病、中性粒细胞计数升高以及下呼吸道症状相关。
（苏欣 审校）
RespirMed. 2016Aug;117:264-71.doi:10.1016/j.rmed.2016.06.019.Epub2016 Jun 25.
Women using bleach for home cleaning are at increased risk of non-allergic asthma.
Matulonga B1, Rava M2, Siroux V3, Bernard A4, Dumas O5, Pin I6, Zock JP7, Nadif R5, Leynaert B8, Le Moual N5.
Author information
Abstract
BACKGROUND:Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma.
AIM:To assess whether the domestic use of bleach for home cleaning is associated with asthma and other respiratory outcomes.
METHODS:Questionnaire-based information on respiratory symptoms and cleaning habits and data from skin prick-tests, bronchial responsiveness challenge and white blood cells were analyzed in 607 women participating in the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Bleach use was evaluated in 3 categories (<1 day/week; 1-3 days/week; 4-7 days/week "frequent").
RESULTS:Overall, 37% of the women reported using bleach weekly. Women using bleach frequently (11%) were more likely to have currentasthma as compared to non-users (adjusted Odds-Ratio (aOR) = 1.7; 95% Confidence Interval (95%CI) 1.0-3.0). Among women with asthma, frequent use of bleach was significantly associated with higher blood neutrophil cell counts. Bleach use was significantly associated with non-allergic asthma (aOR 3.3; 95%CI 1.5-7.1), and more particularly with non-allergic adult-onset asthma (aOR 4.9; 95%CI 2.0-11.6). Consistently, among women without allergic sensitization, significant positive associations were found between use of bleach and bronchial hyperresponsiveness, asthma like-symptoms and chronic cough. No association was observed for allergic asthma.
CONCLUSIONS:Frequent use of bleach for home-cleaning is associated with non-allergic adult-onset asthma, elevated neutrophil counts and lower-airway symptoms in women.
Copyright © 2016 Elsevier Ltd. All rights reserved.
KEYWORDS:Bleach; Cleaning products; Epidemiology; Household irritants; Non-allergic asthma; Respiratory health
RespirMed. 2016Aug;117:264-71.doi:10.1016/j.rmed.2016.06.019.Epub2016 Jun 25.
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