青少年和年轻人的哮喘和睡眠障碍：一项队列研究
2016/08/31
摘要
目的：一个纵向的出生队列提供了一个机会来研究儿童期到成年期的影响。本研究探讨青少年和年轻的成年人的哮喘与睡眠质量和打鼾的横断面关系，以及在14岁时的哮喘、睡眠质量和打鼾可以独立预测或相互预测到21岁时的程度。
方法：数据来自于昆士兰Mater大学妊娠研究，随访妈妈们及其他们的孩子们21年（n = 7223）。收集了5015名受试者在14岁时的哮喘和睡眠信息（问卷数据），3527名受试者在21岁时的哮喘和睡眠信息，以及3237名受试者在14岁和21岁时的哮喘和睡眠信息。
结果：在14岁和21岁时，较差的睡眠质量和打鼾与哮喘独立相关，尤其是女性。在21岁时，相关性主要由哮喘症状的严重性介导。14岁时的哮喘、睡眠质量和打鼾每项都能强烈而独立地预测自己在21岁时的状态。在14岁时的哮喘可以预测到21岁打鼾，而女性睡眠质量差和打鼾可以预测21岁时的哮喘，后者可部分地通过身体质量指数介导。
结论：性别不同，哮喘、睡眠质量与打鼾的关系不同。哮喘的评估和整体管理中应考虑睡眠质量和打鼾。14岁和21岁之间的预测关系为在较轻的一个年龄解决这些问题提供了一个机会。
（杨冬 审校）
J Paediatr Child Health. 2016 Jun 11. doi: 10.1111/jp大的固定气流阻c.13234. [Epub ahead of print]
Asthma and sleep disturbance in adolescents and young adults: A cohort study.
Garden M1, O'Callaghan M1, Suresh S1, Mamum AA2, Najman JM2.
Author information
Abstract
AIMS:A longitudinal birth cohort provides an opportunity to study the impact of childhood conditions persisting into adulthood. This study examines the cross-sectional association of asthma with sleep quality and snoring in the adolescent and young adult population and the extent to which asthma, sleep quality and snoring at 14 years independently predict themselves or each other at 21 years.
METHODS:Data from a 21-year follow-up of mothers and their children recruited into the Mater-University of Queensland Study of Pregnancy (n = 7223). Complete asthma and sleep information (questionnaire data) was available for 5015 participants at 14 years and 3527 at 21 years, with 3237 participants at both 14 and 21 years.
RESULTS:Poor sleep quality and snoring were independently associated with asthma at 14 years and 21 years, with stronger associations evident in women. At 21 years, associations were mediated by asthma symptom severity. Asthma, sleep quality and snoring at 14 years each strongly and independently predicted themselves at 21 years. Asthma at 14 years predicted snoring at 21 years, while poor sleep quality and snoring in women predicted asthma at 21 years, the latter partially mediated by body mass index.
CONCLUSIONS:The relationship between asthma, sleep quality and snoring varied by gender. Sleep quality and snoring should be considered in the assessment and holistic management of asthma. The predictive relationship seen between 14 and 21 years provides an opportunity to address these issues at a younger age.
J Paediatr Child Health. 2016 Jun 11. doi: 10.1111/jp大的固定气流阻c.13234. [Epub ahead of print]
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