用CARAT对有或者没有过敏性鼻炎患者的哮喘控制进行评估：一项初级保健的试验研究
2016/07/28
摘要
背景：哮喘和过敏性鼻炎（AR）是两种慢性炎症性疾病，常伴发。建立了过敏性鼻炎和哮喘的控制测试（CARAT）用以评估从患者的角度对这些疾病的控制，其在没有过敏性鼻炎的哮喘患者中的表现先前没有研究过。
目的：为了检验CARAT可用于评估没有过敏性鼻炎的哮喘患者对哮喘控制这一假设。
方法：在葡萄牙北部的3个主要的医疗保健中心进行了一项横断面研究。在电子病历中确定的成人哮喘患者被邀请来参加。CARAT被用来评估哮喘控制，哮喘控制测试（ACT）被用来作为比较。Spearman相关用来分析没有患过敏性鼻炎的哮喘患者（AsAR）和患有过敏性鼻炎的哮喘患者（AwAR）之间的联系。此外，受试者者操作特征（ROC）曲线分析，总结了曲线下面积（AUC），是用来评估CARAT在筛查没有得到很好控制的哮喘时的表现。
结果：共有103例哮喘患者完成了此项研究，64例（62%）患有过敏性鼻炎的哮喘（AwAR），87例（85%）哮喘控制不好。我们观察到CARAT和ACT评分在所有的哮喘患者和两组中都有很强的相关性：AsAR (r=0.737) ， AwAR (r=0.843)。ROC曲线显示CARAT对AsAR和AwAR组具有良好的分辨力 （AUC分别为 0.894和0.946）。
结论：这些初步的研究结果表明，CARAT类似于其他哮喘控制的评估工具，对患有或者没有过敏性鼻炎的哮喘患者具有良好的判别性能。
（杨冬 审校）
RevPortPneumol(2006). 2016 May-Jun;22(3):163-6.doi:10.1016/j.rppnen.2015.10.014. Epub 2016 Jan 4.
Assessment of asthma control using CARAT in patients with and without Allergic Rhinitis: A pilot study in primary care.
Domingues M1, Amaral R2, Fonseca JA3, Azevedo P4, Correia-de-Sousa J5.
Author information
Abstract
BACKGROUND:Asthma and Allergic Rhinitis (AR) are two chronic inflammatory diseases that are often concomitant. The Control of Allergic Rhinitis and Asthma Test (CARAT) was developed to evaluate the control of these diseases from the patients' perspective. Its performance inasthma patients without AR has not been previously studied.
AIM:To test the hypothesis that CARAT can be used to assess asthma control in patients with asthma and without AR.
METHODS:A cross-sectional study was conducted in 3 primary healthcare centres in Northern Portugal. Adult patients identified in the Electronic Patient Record with a diagnosis of asthma were invited to participate. CARAT was used to assess asthma control and Asthma Control Test (ACT) as a comparator. The associations between asthma patients without AR (AsAR) and with AR (AwAR) were analyzed with Spearman correlation. Additionally, Receiver Operating Characteristic (ROC) curve analysis, summarized by Area Under the Curve (AUC), was used to assess performance of CARAT for screening asthma that was not well-controlled.
RESULTS:A total of 103 asthma patients completed the study, 64 (62%) had AwAR and in 87 (85%) asthma was not well-controlled. We observed a strong correlation between CARAT and ACT scores (r=0.734) in all asthma patients and in both groups: AsAR (r=0.737) and AwAR (r=0.843). ROC curve demonstrated CARAT as having a good discriminative power for both AsAR and AwAR groups (AUC=0.894 and 0.946, respectively).
CONCLUSION:These initial results suggest that CARAT has a good discriminative performance, similar to other asthma control assessment tools, for asthma patients with and without AR.
Copyright © 2015 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.
KEYWORDS:Allergic/diagnosis; Asthma; Control; Portugal; Questionnaires; Rhinitis; Treatment outcome
RevPortPneumol(2006). 2016 May-Jun;22(3):163-6.doi:10.1016/j.rppnen.2015.10.014. Epub 2016 Jan 4.
