胎儿和婴儿的生长模式、气道阻力和学龄期哮喘
2016/07/28
摘要
背景和目的：早产、低出生体重和婴儿体重增加迅速与儿童哮喘症状的风险增加相关。其可能的机制包括持续高气道阻力（Rint）。本研究的目的是研究纵向测量的胎儿和婴儿的生长特性与学龄儿童持续高气道阻力和哮喘之间的联系。
方法：这项研究是嵌入在荷兰鹿特丹以人群为基础的一个前瞻性队列研究中的。在第二和第三孕期用超声来估计胎儿发育。在出生时、3月龄、6月龄和12月龄时测量婴儿生长。在6岁时，测量气道阻力，通过问卷调查获得喘息及哮喘的信息。每个结果分析的受试者数目不同（3954-5066例受试者）。
结果：纵向生长分析表明，学龄儿童的持续气道阻力增加者有较低的胎儿身高增长和体重增加，婴儿身高增长也很慢。直到6岁还有持续性喘息和医生诊断为哮喘的儿童与从来没有喘息或从来没有哮喘的儿童相比，有较高的持续气道阻力（z-scores Rint 的差异分别为: 0.58 (0.19, 0.97) 和0.55 (0.15, 0.95)
结论：学龄儿童的持续气道阻力受到胎儿生长受限的影响，与哮喘患者的预后相关。
（杨冬 审校）
Respirology. 2016 May;21(4):674-82. doi: 10.1111/resp.12718. Epub 2015 Dec 23.
Foetal and infant growth patterns, airway resistance and school-age asthma.
Sonnenschein-van der Voort AM1,2,3, Gaillard R1,3,4, de Jongste JC2, Hofman A3, Jaddoe VW1,3,4, Duijts L2,3,5.
Author information
Abstract
BACKGROUND AND OBJECTIVE:Preterm birth, low birth weight and rapid infant weight gain are associated with increased risks of asthmasymptoms in childhood. The underlying mechanism may include persistently higher airway resistance (Rint). The aim of our study was to examine the associations of longitudinally measured foetal and infant growth characteristics with Rint and asthma outcomes in school-age children.
METHODS:This study was embedded in a population-based prospective cohort study in Rotterdam, The Netherlands. Foetal growth was estimated by ultrasound in the second and third trimesters. Infant growth was measured at birth, 3, 6 and 12 months. At age 6 years, Rint was measured, and information about wheezing and asthma was obtained by questionnaires. The number of subjects per analysis differed per available outcome (3954-5066 subjects).
RESULTS:Longitudinal growth analyses showed that school-age children with increased Rint had lower foetal length growth and weight gain, and lower infant length growth. Children with persistent wheezing until age 6 years and physician-diagnosed asthma had a higher Rint compared with children who never wheezed or without asthma (difference z-scores Rint: 0.58 (0.19, 0.97) and 0.55 (0.15, 0.95), respectively).
CONCLUSION:Rint in school-age children is influenced by foetal growth restriction and is associated with asthma outcomes. See article, page 574.
© 2015 Asian Pacific Society of Respirology.
KEYWORDS:asthma; cohort study; foetal growth; infant growth; wheezing
Respirology. 2016 May;21(4):674-82. doi: 10.1111/resp.12718. Epub 2015 Dec 23.
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用CARAT对有或者没有过敏性鼻炎患者的哮喘控制进行评估：一项初级保健的试验研究
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儿童特应性皮炎的可靠评估的介绍：新的儿童特应性皮炎诊断标准
