我国慢性鼻窦炎的职业和环境危险因素：一项多中心横断面研究
2016/07/28
摘要
背景：慢性鼻窦炎（CRS）定义为在鼻窦粘膜持续炎症超过12周。我们以前报道，CRS的患病率在中国为8%。在这里，我们旨在探讨与CRS有关的职业和环境危险因素。
方法：数据来自七个中国城市：乌鲁木齐、长春、北京、武汉、成都、淮安和广州。CRS诊断根据欧洲鼻窦炎及鼻息肉（EP（3）OS）文件。参与者被要求完成一个标准化的问卷，这是由全球过敏和哮喘欧洲网络（GA（2）LEN）项目发起的问卷调查，覆盖社会人口学特征、CRS相关症状、职业和环境暴露。我们采用比值比（OR）和95%可信区间（95% CI）评估了CRS和各种职业和环境因素之间的关联。
结果：总研究人群包括10633名，根据EP（3）OS标准850名（7.99%） 被诊为患有CRS。我们发现职业和环境因素和CRS之间的关联显著。具体来说，与清洁有关的工作、接触粉尘的职业，暴露于有毒气体的职业，家里有宠物或家里、工作场所有地毯都是CRS的危险因素。此外，用于冬季取暖的方法、夏季使用空调的时间、接触发霉或潮湿环境的频率在有或者没有CRS的受试者中明显不同。
结论：我们的数据表明，一些职业和环境暴露与CRS密切相关，这有助于了解CRS流行病学。
（杨冬 审校）
Respir Res. 2016 May 17;17(1):54. doi: 10.1186/s12931-016-0366-z.
Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study.
Gao WX1, Ou CQ2, Fang SB1, Sun YQ1, Zhang H3, Cheng L4, Wang YJ5, Zhu DD6, Lv W7, Liu SX8, Li PZ9, Xu G1, Shi J10, Fu QL11.
Author information
Abstract
BACKGROUND:Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS.
METHODS:Data were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP(3)OS) document. Participants were asked to complete a standardized questionnaire, which was developed by the Global Allergy and Asthma European Network (GA(2)LEN) project and covered sociodemographic characteristics, CRS-related symptoms and occupational and environmental exposures. We evaluated the association between CRS and various occupational and environmental factors using odds ratios (ORs) and 95 % confidence intervals (95 % CIs).
RESULTS:The total study population consisted of 10,633 subjects, 850 (7.99 %) of whom were defined as having CRS according to the EP(3)OS criteria. We found that there were significant associations between occupational and environmental factors and CRS. Specifically, having a clearance-related job, occupational exposure to dust, occupational exposure to poisonous gas, a pet at home or carpet at home or at the workplace were risk factors for CRS. Additionally, the method used to keep warm in winter, the duration of time spent using air conditioning in summer and the frequency of exposure to mouldy or damp environments were significantly different in subjects with and without CRS.
CONCLUSIONS:Our data showed that some occupational and environmental exposures are strongly associated with CRS, which aids in understanding the epidemiology of CRS.
Respir Res. 2016 May 17;17(1):54. doi: 10.1186/s12931-016-0366-z.
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