在实验羊慢性哮喘模型中，肿瘤抑素对血供、气道炎症反应和肺功能的影响
2016/07/27
摘要
肿瘤抑素，一个IV型胶原α-3链蛋白的片段，在哮喘患者气道中显著减少。此外，有证据表明肿瘤抑素的相对低水平，与诱导变应性气道疾病中的血管生成和炎症反应有关。在这里，我们表明，段内给予肿瘤抑素可以阻碍节段性激发实验羊哮喘模型诱导产生的血管重塑和变应性炎症反应的形成。特别是，与对照组相比，对慢性暴露于屋尘螨（HDM）的肺段给予肿瘤抑素导致直径范围在10(+)-20 μm的气道小血管显著减少。屋尘螨激发后，用肿瘤抑素治疗的肺段内，肺实质、气道组织和支气管肺泡灌洗液中的嗜酸性粒细胞数量均显著降低。与生理盐水治疗（对照组）的肺段相比，肿瘤抑素处理的肺段气道平滑肌细胞中VEGF的表达同样显著降低。在这个模型中，给予肿瘤抑素的过敏性肺功能反应没有衰减。这些数据与肿瘤抑素可以抑制过敏性气道疾病的血管重塑和炎症反应这一观念一致。
（苏欣 审校）
Sci Rep. 2016 May 20;6:26309. doi: 10.1038/srep26309.
The Effects of Tumstatin on Vascularity, Airway Inflammation and Lung Function in an Experimental Sheep Model of Chronic Asthma.
Van der Velden J1, Harkness LM2,3, Barker DM1, Barcham GJ1, Ugalde CL1, Koumoundouros E4, Bao H1, Organ LA1, Tokanovic A1, Burgess JK2,3,5,Snibson KJ1.
Author information
Abstract
Tumstatin, a protein fragment of the alpha-3 chain of Collagen IV, is known to be significantly reduced in the airways of asthmatics. Further, there is evidence that suggests a link between the relatively low level of tumstatin and the induction of angiogenesis and inflammation in allergic airway disease. Here, we show that the intra-segmental administration of tumstatin can impede the development of vascular remodelling and allergic inflammatory responses that are induced in a segmental challenge model of experimental asthma in sheep. In particular, the administration of tumstatin to lung segments chronically exposed to house dust mite (HDM) resulted in a significant reduction of airway small blood vessels in the diameter range 10(+)-20 μm compared to controls. In tumstatin treated lung segments after HDM challenge, the number of eosinophils was significantly reduced in parenchymal and airway wall tissues, as well as in the bronchoalveolar lavage fluid. The expression of VEGF in airway smooth muscle was also significantly reduced in tumstatin-treated segments compared to control saline-treated segments. Allergic lung function responses were not attenuated by tumstatin administration in this model. The data are consistent with the concept that tumstatin can act to suppress vascular remodelling and inflammation in allergic airway disease.
Sci Rep. 2016 May 20;6:26309. doi: 10.1038/srep26309.
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循环MicroRNAs：与哮喘肺功能的关系
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