中国哮喘危险因素中的环境与遗传易感性现状
2016/05/26
摘要
哮喘是世界上最常见的慢性肺部疾病，给社会带来了相当大的经济负担。中国是世界上最大的发展中国家，人口最多。在过去的几十年里，中国发生了巨大的变化。传统的生活方式和生活环境已改变，直接影响哮喘的患病率。中国儿童和成人哮喘的患病率比发达国家低，但在过去30年中，哮喘的患病率一直在上升。中国各地区的患病率明显不同。多基因多态性和由PM2.5、PM10、SO2、NO2、环境烟草烟雾和煤等造成的室外空气污染，室内污染，与吸入性过敏原，如屋尘螨、花粉、蟑螂颗粒等，都是哮喘的危险因素。
（苏欣 审校）
Allergy Asthma ImmunolRes. 2016 Mar;8(2):92-100.doi:10.4168/aair.2016.8.2.92. Epub 2015 Aug 21.
Environmental Exposure and Genetic Predisposition as Risk Factors for Asthma in China.
Chen Y1,2, Wong GW3, Li J4.
Author information
Abstract
Asthma is the most common chronic pulmonary disease worldwide and places a considerable economic burden on society. China is the world's largest developing country and has the largest population. China has undergone dramatic changes in the past few decades. The traditional lifestyle and living environment have changed in ways that directly affect the prevalence of asthma. The prevalence of asthma is lower in Chinese children and adults than in developed countries, but the prevalence has been on the rise during the past 30 years. The prevalence significantly varies among different parts of China. Polymorphisms of multiple genes, outdoor air pollution caused by PM2.5, PM10, SO₂, NO₂, environmental tobacco smoke, and coal, indoor pollution, and inhaled allergens, such as house dust mites, pollen, and cockroach particles, are risk factors for asthma.
KEYWORDS:Asthma; air pollution; allergen; genetic polymorphism
Allergy Asthma ImmunolRes. 2016 Mar;8(2):92-100.doi:10.4168/aair.2016.8.2.92. Epub 2015 Aug 21.
