老年哮喘：胆碱补充的影响
2016/05/26
摘要
背景：对老年人的哮喘认知很少，这是因为很少有研究涉及这类人群。DNA甲基化可影响哮喘易感基因的表达。甲基基团可以通过胆碱依赖的途径产生。哮喘患者血清胆碱水平降低。我们研究了老年哮喘补充胆碱的效果和不同参数基线水平的相互关系。
方法：这是一项双盲、安慰剂对照、交叉研究。对30个65岁以上的哮喘患者在基线和3、6、9、12周后进行评价。他们随机每天两次服用胆碱酒石酸盐310毫克和安慰剂胶囊，共服用6周。
结果：90%的研究对象是敏感体质和97%的人使用吸入糖皮质激素。胆碱补充与安慰剂不影响哮喘控制测试（ACT）、肺功能测定值、嗜酸性粒细胞计数、血清总IgE（所有的比较都是P>0.86）。在ACT打分较低（≤20）、FEV1 %较低（＜60%）、或者高嗜酸性粒细胞计数（≥0.6）的受试者中，胆碱组和安慰剂组之间均无差异（P＞0.63）。ACT较低或吸入性类固醇剂量更高的受试者中，我们在嗜酸性粒细胞计数、IgE和其它参数在基线水平没有发现明显的相关性（P＞0.09）。与男性相比，患哮喘的妇女有较低的基线ACT分数（P = 0.02）。
结论：在这项老年哮喘患者的研究中，补充胆碱6周不影响ACT评分、肺功能测定值、外周血嗜酸性粒细胞或血清总IgE。这些结果将需要更大的样本量和更长时间的研究来确证。
（苏欣 审校）
Allergy Asthma ClinImmunol. 2016 Mar 11;12:15.doi:10.1186/s13223-016-0121-5.eCollection 2016.
Asthma in the elderly: the effect of choline supplementation.
Columbo M1, Rohr AS1.
Author information
Abstract
BACKGROUND:Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a choline dependent pathway. Asthmatics have decreased serum choline. We studied the effect of choline supplementation in elderly asthmatics and associations between different parameters at baseline.
METHODS:This is a double-blind, placebo-controlled, cross-over study. Thirty asthmatics 65 years old and older were evaluated at baseline and 3, 6, 9, and 12 weeks later. They randomly received choline bitartrate 310 mg and placebo capsules twice daily for 6 weeks.
RESULTS:Ninety percent of the study subjects were atopic and 97 % of them were using inhaled corticosteroids. Choline supplementation did not affect ACT (asthma control test), spirometric values, eosinophil counts or total serum IgE vs. placebo (p > 0.86 for all comparisons). In subjects with lower ACT (≤20), lower FEV1 % (<60 %), or higher eosinophil counts (≥0.6), there was similarly no difference between choline and placebo (p > 0.63). We found no significant association between eosinophil counts and IgE and the other parameters at baseline including in subjects with lower ACT or on higher inhaled steroid doses (p > 0.09). Asthmatic women had lower baseline ACT scores compared to men (p = 0.02).
CONCLUSIONS:In this study of elderly asthmatics, choline supplementation for 6 weeks did not affect ACT scores, spirometric values, peripheral blood eosinophils, or total serum IgE. These results will require confirmation in larger and longer studies. Trial registration ClinicalTrials.govNCT02371993.
KEYWORDS:Asthma; Choline; Elderly
Allergy Asthma ClinImmunol. 2016 Mar 11;12:15.doi:10.1186/s13223-016-0121-5. eCollection 2016.
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使用低剂量的短程维生素D补充改善儿童时期哮喘的控制：一项随机、双盲、安慰剂对照的研究
