哮喘联盟

   摘要
   背景：在我们既往的关于预防流行性感冒的随机研究中，哮喘发作作为次要结果与安慰剂组相比较少发生在维生素D组。我们的目的是为了阐明除了标准治疗之外低剂量的短程维生素D补充是否可以改善儿童时期哮喘的控制。
   方法：我们发起了一项随机、双盲、安慰剂对照的研究将维生素D3补充剂(800 IU/天)与安慰剂对患有哮喘的学龄儿童2个月的治疗进行了比较。主要终点为哮喘发作的频率和严重程度，由全球哮喘防治创议(GINA)定义的哮喘控制水平的变化判定，在2个月和6个月随访时由医生诊断。
   结果：日本的患有哮喘的学龄儿童 (n=89)被随机分配接受维生素D (n=54)或安慰剂(n=35)。在第二个月，与安慰剂组相比，维生素D组的GINA哮喘控制改善更显著(P=0.015)。在第二个月时，与安慰剂组相比，做为次要终点的儿童哮喘控制试验(CACT)评分仍是在维生素D组改善更显著(P=0.004)，而且到了6个月时差异仍然显著(P=0.012)。在6个月时，维生素D组(8/54: 15%)呼气流量峰值＜80%预计值的患者比例明显少于安慰剂组(12/35: 34%) (P=0.032)。
   结论：除了标准治疗之外，低剂量、短程的维生素D补充可能能改善学龄儿童哮喘控制的水平。
 

（杨冬 审校）
Allergy. 2016 Feb 3.doi: 10.1111/all.12856. [Epub ahead of print]

Improved Control of Childhood Asthma with Low-Dose, Short-Term Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Trial.
 

Tachimoto H1, Mezawa H1,2, Segawa T1,3, Akiyama N1,3, Ida H1, Urashima M1,2.

 

Abstract
BACKGROUND:In our prior randomized trial on preventinginfluenza, asthma attacks as a secondary outcome occurred less often in the vitamin D group than the placebo group. We aimed to clarify whether low-dose, short-term vitamin D supplementation, in addition to standard treatments, improves control of childhood asthma.
METHODS:We conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D3 supplements (800 IU/day) with placebo for 2 months in schoolchildren with asthma. The primary outcomes were frequency and severity of asthma judging from changes of asthma control levels defined by the Global Initiative for Asthma (GINA) by collaborating doctors at 2 and 6 months.
RESULTS:Japanese schoolchildren with asthma (n=89) were randomly assigned to receive vitamin D (n=54) or placebo (n=35). At 2 months, GINAasthma control was significantly more improved in the vitamin D group compared with the placebo group (P=0.015). Childhood asthma control test (CACT) scores, a secondary outcome, were also significantly (P=0.004) improved in the vitamin D group compared with the placebo group at 2 months, and differences remained significant (P=0.012) at 6 months. The proportion of patients with a peak expiratory flow rate <80% predicted was significantly less in the vitamin D group (8/54: 15%) than the placebo group (12/35: 34%) at 6 months (P=0.032).
CONCLUSIONS:Low-dose, short-term vitamin D supplementation in addition to standard treatment may improve levels of asthma control in schoolchildren.
 

Allergy. 2016 Feb 3.doi: 10.1111/all.12856. [Epub ahead of print]