哮喘联盟

   摘要
   关于健康饮食习惯对于哮喘控制的益处的严谨研究是很少的。我们随机选取90名患有经确诊的未受控制哮喘且低质量饮食 (终止高血压膳食疗法 (DASH) 评分<6 ，共9分) 的成人，进行6个月的DASH行为干预(n=46) 或常规治疗控制(n=44)。意向性分析采用重复测量混合模型。受试者为中年人，67%为女性，且为多民族。与对照组相比，6个月后，干预组受试者的DASH 评分 (平均变化(95% CI) 0.6 (0, 1.1) vs -0.3 (-0.8, 0.2); 平均差0.8 (0.2, 1.5)) 、主要结果和哮喘控制问卷评分 (-0.2 (-0.5, 0) vs 0 (-0.3, 0.3); 平均差-0.2 (-0.5, 0.1))有所改善。相较于对照组，小型哮喘生活质量问卷的总评分和子评分变化的平均组间差异更支持干预组：总评分0.4 (95% CI 0, 0.8)、症状评分0.5 (0, 0.9)、环境评分0.4 (-0.1, 1.0)、情绪评分0.4 (-0.2, 0.9)和活动评分0.3 (0, 0.7)。这些差异不大，但是有潜在的临床意义。DASH行为干预改善了膳食质量，可使未控制的哮喘成人患者获得更好的哮喘控制和功能状态。一项全面的功效试验是十分必要的。

 

（苏欣 审校）
Eur Respir J. 2016 Jan;47(1):122-32. doi: 10.1183/13993003.00591-2015. Epub 2015 Oct 22.


 

Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma.
 

Ma J1, Strub P2, Lv N3, Xiao L3, Camargo CA Jr4, Buist AS5, Lavori PW6, Wilson SR7, Nadeau KC8, Rosas LG7.
 

Abstract
Rigorous research on the benefit of healthy eating patterns for asthma control is lacking. We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models. Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus -0.3 (-0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (-0.2 (-0.5, 0) versus 0 (-0.3, 0.3); difference -0.2 (-0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (-0.1, 1.0), emotions 0.4 (-0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant. The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.
 

Eur Respir J. 2016 Jan;47(1):122-32. doi: 10.1183/13993003.00591-2015. Epub 2015 Oct 22.