哮喘联盟

   摘要
   综述的目的：肥胖对哮喘的控制和急性发作的风险具有显著的负面作用。本综述的目的是讨论最近评价减重对肥胖成人患者哮喘控制的影响的研究。 
   最新发现:临床研究显示肥胖患者的减重与改善症状，控制器药物的使用和哮喘相关生活质量，以及减少严重急性发作的风险有关。而且，一些研究也显示减重能够改善肺功能与气道反应性，最近发现肥胖外科手术后的减重对于哮喘患者的小气道功能、系统性炎症和支气管炎症具有改善作用，这可能解释了观察到的症状控制和肺功能的改善。
   总结:肥胖成人哮喘患者的减重会引起哮喘控制的全面改善，包括气道高反应性和炎症。减重须作为肥胖哮喘患者控制哮喘的基础。
 

（苏欣 审校）
Curr Opin Pulm Med. 2016 Jan;22(1):69-73. doi: 10.1097/MCP.0000000000000226.

 

Asthma and obesity: is weight reduction the key to achieve asthma control?
 

Ulrik CS1.

Abstract
PURPOSE OF REVIEW:Obesity has significant negative impact on asthma control and risk of exacerbations. The purpose of this review is to discuss recent studies evaluating the effects of weight reduction on asthma control in obese adults.
RECENT FINDINGS:Clinical studies have shown that weight reduction in obese patients is associated with improvements in symptoms, use of controller medication, and asthma-related quality of life together with a reduction in the risk for severe exacerbations. Furthermore, several studies have also revealed improvements in lung function and airway responsiveness, and more recently it has been shown that weight reduction following bariatric surgery has positive impact on small airway function, systemic inflammation and bronchial inflammation in this group of patients, which may explain the observed improvements in symptom control and lung function.
SUMMARY:Weight reduction in obese adults with asthma leads to an overall improvement in asthma control, including airway hyperresponsiveness and inflammation. Weight reduction should be a cornerstone in the management of obese patients with asthma.
 

Curr Opin Pulm Med. 2016 Jan;22(1):69-73. doi: 10.1097/MCP.0000000000000226.