哮喘联盟

   摘要
   本研究的目的是对关于孕妇产前心理应激与随后的幼儿发生哮喘和气喘的关系的观察性研究进行系统性回顾和meta分析。通过电子数据库 (PubMed、Embase、PsycInfo和 Web of Science)对全部可获得的1960年到2013年11月期间发表的文献进行了系统性地搜索。所有评价了任意形式的孕妇产前心理应激与子女的呼吸系统疾病发病率关系的观察性研究均被纳入。进行数据提取、质量评价和meta分析。总的meta分析包括了10项研究，且表明：孕期暴露于或经历了心理应激的母亲，其孩子的气喘、哮喘和其他呼吸系统症状的发病率要高于未暴露于和未经历心理应激的母亲的孩子 ( 合并OR 1.56 (95% CI 1.36-1.80))。压力暴露、知觉压力、哮喘和气喘亚组分析的结果是可比较的。本研究说明孕妇产前心理应激与子女的呼吸系统疾病（包括哮喘和气喘）发病相关。未来寻找哮喘和气喘的早期病因的研究需要考虑到孕妇产前心理应激的影响。
 

（苏欣 审校）
Eur Respir J. 2016 Jan;47(1):133-46. doi: 10.1183/13993003.00299-2015. Epub 2015 Nov 5.


 

Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis.
 

van de Loo KF1, van Gelder MM2, Roukema J3, Roeleveld N4, Merkus PJ5, Verhaak CM6.
 

Abstract
The aim of this study was to systematically review and meta-analyse observational studies on prenatal maternal psychological stress and the subsequent development of asthma and wheezing in early childhood.All available published literature from 1960 until November 2013 was systematically searched through electronic databases (PubMed, Embase, PsycInfo and Web of Science). All observational studies assessing associations between any form of prenatal maternal psychological stress and respiratory morbidity in the child were included. Data extraction, quality assessment and meta-analyses were performed. The overall meta-analysis included 10 studies and showed that the prevalence of wheezing, asthma and other respiratory symptoms is higher in children of mothers who were exposed to or experienced some form of psychological stress during pregnancy than in mothers who did not (pooled OR 1.56 (95% CI 1.36-1.80)). Comparable results were observed in subgroup analyses of stress exposure, perceived stress, asthma and wheezing. This study demonstrates that prenatal maternal psychological stress is associated with respiratory morbidity, including asthma and wheezing in the child. Future studies examining the early origins of asthma and wheezing need to account for the impact of prenatal maternal stress.
 

Eur Respir J. 2016 Jan;47(1):133-46. doi: 10.1183/13993003.00299-2015. Epub 2015 Nov 5.