哮喘联盟

   摘要
   目的：一些研究表明，母亲孕期使用对乙酰氨基酚与后代患哮喘相关，咖啡会改变对乙酰氨基酚的毒性。我们旨在研究母亲孕期使用对乙酰氨基酚是否会增加后代患哮喘的风险以及母亲饮用咖啡是否会改变这种潜在的相关性。
   方法：我们共纳入63652名在丹麦国家出生队列研究注册的活产独生子女。通过填写问卷调查表和3次计算机辅助电话采访，对母亲孕期对乙酰氨基酚的使用和咖啡的饮用情况进行了评估。通过使用丹麦国家患者登记系统和丹麦国家处方登记系统，对哮喘病例进行了鉴别。我们通过使用Cox比例风险回归模型，根据产前的对乙酰氨基酚和咖啡暴露，对哮喘的风险比(HRs)进行了评估。
   结果：校正了潜在的混杂因素后，孕期对乙酰氨基酚暴露与后代患哮喘的风险增加相关(HR = 1.16, 95% CI: 1.11-1.22)。孕期饮用咖啡与后代患哮喘的风险轻度降低相关(HR = 0.94, 95%CI: 0.90-0.99)。但是没有有力的证据支持咖啡的饮用会改变对乙酰氨基酚的使用对哮喘的影响。
   结论：孕期对乙酰氨基酚的使用与后代患哮喘风险的适度增加相关，而这种相关性不受饮用咖啡的影响。

 

（苏欣 审校）
Pharmacoepidemiol Drug Saf. 2015 Dec 16. doi: 10.1002/pds.3940. [Epub ahead of print]
 

Association of prenatal exposure to acetaminophen and coffee with childhood asthma.
 

Liu X1, Liew Z2, Olsen J1,2, Pedersen LH3, Bech BH1, Agerbo E4,5, Yuan W6, Li J7.
 

Abstract
PURPOSE:Some studies have suggested that maternal acetaminophen use during pregnancy is associated with asthma in the offspring, and coffee consumption may modify the toxicity of acetaminophen. We aim to examine whether pregnancy maternal acetaminophen use increases the risk for offspring asthma, and whether such a potential association could be modified by maternal coffee consumption.
METHODS:We included 63 652 live-born singletons enrolled in the Danish National Birth Cohort. Maternal acetaminophen use and coffee consumption during pregnancy were assessed prospectively via the enrolment questionnaire and three computer-assisted telephone interviews. Asthma cases were identified by using the Danish National Patient Register and the Danish National Prescription Registry. We estimated the hazard ratios (HRs) for asthma according to prenatal acetaminophen and coffee exposure using Cox proportional hazards regression model.
RESULTS:After adjusting for potential confounders, acetaminophen use during pregnancy was associated with an increased risk of offspring asthma (HR = 1.16, 95% confidence interval (CI): 1.11-1.22). Coffee drinking during pregnancy was associated with a slightly decreased risk (HR = 0.94, 95%CI: 0.90-0.99). But there was no strong evidence of effect measure modification of acetaminophen use on offspring asthma by coffee consumption.
CONCLUSIONS:Acetaminophen use during pregnancy was associated with a modest increased risk for offspring asthma, which was not modified by coffee consumption.
 

Pharmacoepidemiol Drug Saf. 2015 Dec 16. doi: 10.1002/pds.3940. [Epub ahead of print]