哮喘联盟

   摘要
   目的/假设：慢性鼻窦炎(CRS)是鼻旁窦的炎性疾病，与生活质量的降低和保健服务使用的增加相关。尽管CRS与哮喘的相关程度尚不清楚，但慢性上、下呼吸道疾病常共存。为了弄清楚CRS对哮喘的影响，我们采用了一项先前的全国性纵向调查的数据。
   方法：我们采用了1998/1999-2010/2011年加拿大全国人口健康调查的受调查者的数据。分析了11,555（66.9%）例19岁以上的基线无哮喘患者的数据。对这些受调查者进行了12年的随访，以确定哮喘的累积发病率。使用逻辑回归来评估CRS对哮喘发展的影响，并校正了年龄、性别、身体质量指数、吸烟和食物或非食物相关的过敏。
   结果：在为期12年的研究中，6% (95% CI: 5.4%-6.7%)的受调查者发展为哮喘。基线CRS(OR: 2.7, 95% CI: 1.9-3.9)、女性(OR: 1.4, 95% CI: 1.1-1.8)和过敏(OR: 2.6, 95% CI: 2.1 - 3.3)与发展为哮喘显著相关。在校正之后，相对于非CRS的受调查者，患有CRS的受调查者更有可能发展成为哮喘(OR: 2.0, 95% CI: 1.4-2.9)。
   结论：结果表明：13例CRS患者中的一例随后将会被诊断为哮喘。考虑到与哮喘相关的经济负担和保健服务的使用，对CRS提供管理的人需要增强意识并随后治疗哮喘。
 

（苏欣 审校）
Laryngoscope. 2015 Dec 21. doi: 10.1002/lary.25831. [Epub ahead of print]

 

A population-based study investigating chronic rhinosinusitis and the incidence of asthma.
 

Habib AR1,2, Javer AR1, Buxton JA2.
 

Abstract
OBJECTIVES/HYPOTHESIS:Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses, associated with reduced health-related quality of life and increased utilization of healthcare services. Chronic upper and lower respiratory diseases often coexist, although the extent to which CRS is associated with developing asthma remains unclear. To investigate the effect of CRS on receiving a subsequent diagnosis of asthma, we used data from a previously conducted national, longitudinal survey.
METHODS:Respondents from the Canadian National Population Health Survey from 1998/1999 to 2010/2011 were used. Data were analyzed from 11,555 (66.9%) subjects, ≥ 19 years of age and reporting no asthma at baseline. Respondents were reviewed for 12 years to determine the cumulative incidence of asthma. Logistic regression was used to estimate the effect of CRS on the development of asthma, adjusting for age, gender, body mass index, cigarette smoking, and food- or nonfood-related allergies.
RESULTS:During the 12-year study period, 6.0% (95% confidence interval [CI] [95% CI]: 5.4%-6.7%) of respondents developed asthma. Baseline CRS (odds ratio [OR]: 2.7, 95% CI: 1.9-3.9), female gender (OR: 1.4, 95% CI: 1.1-1.8), and allergies (OR: 2.6, 95% CI: 2.1 - 3.3) were significantly associated with developing asthma. After adjustment, respondents with CRS were significantly more likely to develop asthma than non-CRS counterparts (OR: 2.0, 95% CI: 1.4-2.9).
CONCLUSION:Results indicate that one in 13 individuals with CRS will be subsequently diagnosed with asthma. Given the economic burden and use of healthcare services associated with asthma, providers managing CRS may consider increased awareness and subsequent treatment for asthma.
 

Laryngoscope. 2015 Dec 21. doi: 10.1002/lary.25831. [Epub ahead of print]