哮喘联盟

   摘要
   背景与目的：早期研究提示，与对照组相比，哮喘患者的体力活动水平产生了不同的结果。我们曾经报道过，高度与中度水平的体力活动与较高的喘息发病率相关，尤其是女性。本文中，我们研究了年轻哮喘患者和健康受试者的体力活动水平，以及他们对哮喘控制的影响。
   方法：408名经医生诊断为哮喘的患者和118例对照（10-34岁），回答了体力活动频率、和/或者体力活动时间的问题、进行了哮喘控制测试（ACT）、肺活量、乙酰甲胆碱激发试验和呼出一氧化氮检测。
   结果：与对照组相比，哮喘患者体力活动更频繁（P = 0.01  ），持续时间更长（P = 0.002  ）。体力活动按频率（40.6% vs 24.1%，P=0.001  ）或活动时间（39% vs 21.7%，P＜0.001  ）评估，高度和中度体力活动的哮喘患者，哮喘控制不良发生率升高（ACT < 20）。这种现象仅见于ACT减少的女性患者（P < 0.05）。女性频繁体力劳动与中度体力活动相比ACT<20的比值比为4.81（2.43，9.51）。而在男性中没有同样的效果（比例为1.18（0.61，2.30））。这种相互作用与性别显著相关（P = 0.003  ）。而中度和高度体力活动的女性哮喘患者的呼出一氧化氮或乙酰甲胆碱激发试验未发现明显差异。
   结论：年轻的哮喘患者比对照组更活跃。以ACT作为判断标准，女性，而非男性，高水平的体力活动与哮喘控制不良相关。与关气道炎症或气道反应无关。
 

（杨冬 审校）
Respirology. 2015 Nov 19.doi: 10.1111/resp.12671. [Epub ahead of print]

 

High levels of physical activity are associated with poorer asthma control in young females but not in males.
 

Lövström L1, Emtner M2,3, Alving K4, Nordvall L4, Borres MP4, Janson C3, Malinovschi A1.
 

Abstract
BACKGROUND AND OBJECTIVE:Earlier studies on the levels of physical activity in asthma patients compared with controls have yielded varying results. We have previously reported that high versus moderate levels of physical activity were associated with higher prevalence of wheezing, especially in females. Here we studied the levels of physical activity in young patients with asthma and healthy subjects and their effect on asthma control.
METHODS:Four hundred eight physician-diagnosed patients with asthma and 118 controls (10-34 years) answered questions concerning frequency and/or duration of physical activity and undertook the Asthma Control Test (ACT), spirometry, methacholine challenges and exhaled nitric oxide measurements.
RESULTS:Asthma patients were more frequently physically active (P = 0.01) and for longer durations (P = 0.002) than controls. Highly versus moderately physically active patients with asthma had a higher prevalence of not well-controlled asthma (ACT < 20) when physical activity was assessed by frequency (40.6% vs 24.1%, P = 0.001) or duration (39.0% vs 21.7%, P < 0.001). This was only seen in females who had reduced ACT items (P < 0.05). Frequently versus moderately active females had an odds ratio of 4.81 (2.43, 9.51) to have ACT < 20, while no such effect was found in males (OR 1.18 (0.61, 2.30)) and this interaction was statistically significantly associated with gender (P = 0.003). No differences in fraction of exhaled nitric oxide or methacholine reactivity were found between moderately and highly physically active females with asthma.
CONCLUSION:Young asthma patients were more active than controls. High levels of physical activity were associated with poor asthma control as judged by the ACT in females, but not in males, and this appears unrelated to airway inflammation or responsiveness.
 

Respirology. 2015 Nov 19.doi: 10.1111/resp.12671. [Epub ahead of print]