哮喘联盟

   摘要
   背景：摩洛哥坚果在世界范围内被用于众多的美容产品中，因为这种水果被认为对健康有许多益处。随着摩洛哥坚果应用的增加，新的过敏病例也随之增加。我们调查了被一家化妆品厂雇佣的，并且常与坚果粉接触的所有工人，来明晰与接触摩洛哥坚果有关的过敏。
   方法：在职业病科患者接受了调查，根据他们的症状，进行肺功能测试，乙酰甲胆碱激发试验，对坚果粉的特异性吸入激发试验，皮肤点刺试验和免疫印迹分析。
   结果：我们报告了3例摩洛哥坚果粉引发的职业性哮喘和疑似鼻炎1例。15种坚果蛋白可被患者的IgE识别。蛋白识别，对坚果的交叉反应和ELISA抑制试验提示，一些坚果过敏原能与榛子过敏原发生体外交叉反应，包括11S球蛋白和豌豆球蛋白。
   结论：与摩洛哥坚果粉高水平的接触应该被认为是一种由IgE介导的过敏的潜在病因，对处理摩洛哥坚果粉的工人应进行详细的调查。
 

（杨冬 审校）
Allergy. 2015 Nov 25.doi: 10.1111/all.12811. [Epub ahead of print]
 

First evidence of occupational asthma to argan powder in a cosmetic factory.
 

Paris C1,2, Herin F3,4,5, Penven E1,2, Thaon I1,2, Richard C6, Jacquenet S6, Barbaud A2,7, Poussel M8,9.
 

Abstract
BACKGROUND:Argan is used worldwide in numerous cosmetic products, as this fruit is supposed to have many beneficial properties on health. New cases of allergy can be expected with the growing use of argan. We investigated all workers (9) employed by a cosmetic factory and exposed to argan powder to identify possible allergies related to exposure to argan powder.
METHODS:Patients were investigated in the occupational disease department and, according to their symptoms, underwent pulmonary function testing, methacholine challenge, specific inhalation challenge to argan powder, skin prick tests and immunoblotting analysis.
RESULTS:We report three cases of occupational asthma to argan powder and a probable case of rhinitis. Fifteen argan proteins were recognized by the patients' IgE. Identification of proteins, cross-reactions to nuts and ELISA inhibition tests suggested that some argan allergens can cross-react in vitro with hazelnut allergens, including 11S globulin and vicilin.
CONCLUSION:High-level exposure to argan powder should be considered to be a potential cause of IgE-mediated allergy and workers handling argan powder should be carefully investigated.
 

Allergy. 2015 Nov 25.doi: 10.1111/all.12811. [Epub ahead of print]