哮喘联盟

   摘要
   本研究旨在对有关孕妇产前心理压力和儿童早期哮喘、喘息的观察性研究进行系统综述和荟萃分析。系统搜索了电子数据库（PubMed、Embase、PsycInfo及Web of Science)中1960年至2013年11月所有已发表的文献。纳入所有评估孕妇产前各种形式心理压力与儿童呼吸系统疾病关系的观察性研究，并进行数据提取、质量评价和荟萃分析。共有10项研究纳入荟萃分析，结果显示，与产前无心理压力的母亲相比，产前有过心理压力的母亲所生的孩子儿童期喘息、哮喘或其他呼吸道症状发生率更高（汇总OR = 1.56 95% CI : 1.36 - 1.80）。类似的结果也出现在压力暴露、压力感、哮喘与喘息的亚组分析中。本研究证实，孕妇产前心理压力与儿童呼吸道疾病包括哮喘和喘息有关。将来有关哮喘和喘息起因的研究，有必要考虑到其母亲产前心理压力的影响。
 

（杨冬 审校）
Eur Respir J. 2015 Nov 5. pii: ERJ-00299-2015. doi: 10.1183/13993003.00299-2015. [Epub ahead of print]
 

Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis.
 

van de Loo KF1, van Gelder MM2, Roukema J3, Roeleveld N4, Merkus PJ5, Verhaak CM6.
 

Abstract
The aim of this study was to systematically review and meta-analyse observational studies on prenatal maternal psychological stress and the subsequent development of asthma and wheezing in early childhood.All available published literature from 1960 until November 2013 was systematically searched through electronic databases (PubMed, Embase, PsycInfo and Web of Science). All observational studies assessing associations between any form of prenatal maternal psychological stress and respiratory morbidity in the child were included. Data extraction, quality assessment and meta-analyses were performed. The overall meta-analysis included 10 studies and showed that the prevalence of wheezing, asthma and other respiratory symptoms is higher in children of mothers who were exposed to or experienced some form of psychological stress during pregnancy than in mothers who did not (pooled OR 1.56 (95% CI 1.36-1.80)). Comparable results were observed in subgroup analyses of stress exposure, perceived stress, asthma and wheezing. This study demonstrates that prenatal maternal psychological stress is associated with respiratory morbidity, including asthma and wheezing in the child. Future studies examining the early origins of asthma and wheezing need to account for the impact of prenatal maternal stress.
 

Eur Respir J. 2015 Nov 5. pii: ERJ-00299-2015. doi: 10.1183/13993003.00299-2015. [Epub ahead of print]