哮喘与身体质量指数和社会经济地位之间的关联：基于849 659名青少年的一项横断面研究
2015/12/03
摘要
背景和目的：哮喘与身体质量指数（BMI）相关，但其与社会经济状况（SES）的相关性是有争议的。SES和BMI对哮喘患病率的联合作用是不确定的。
方法：17岁入伍前的以色列国防军进行例行体检。SES是根据居住地的既定标准确定的。研究人群是根据经典的体重和三个SES（低，中，高）分组。单变量和多变量Logistic回归模型被用于评估BMI和SES组哮喘患病率的比值比（OR）。对BMI和SES的组合效应也进行了计算。
结果：849 659名研究对象包括480 993 例男性（9.5%哮喘患病率）和368666例女性（6.7% 哮喘患病率）。女性中，对于哮喘，BMI的增加与OR的增加相关（肥胖患者与正常体重相比OR 1.44，95% CI 1.36-1.52）。男性呈现了J形曲线（对于肥胖患者OR 1.24 95% CI 1.2-1.29 ,对于体重过轻患者OR 1.12, 95% CI 1.08-1.16 ,均与正常体重相比)。调整到SES后，OR也未发生明显变化。所有SES组产生一个线性曲线（女性1.59，95% CI 1.53-1.66和男性1.79，95%cl 1.74-1.84）。调整SES到BMI，OR值未发生明显改变。当各组与正常体重/低SES组相比，肥胖/高SES组OR最高（女性2.32，95% CI 2.05-2.64和男性1.99，95%CL 1.83-2.13）。
结论：在青少年男性和女性中，BMI和SES分别独立地与哮喘相关。
（苏欣 审校）
Respirology. 2015 Sep 22. doi: 10.1111/resp.12645. [Epub ahead of print]
Association between asthma and body mass index and socioeconomic status: A cross-sectional study on 849 659 adolescents.
Gordon B1,2, Hassid A1, Bar-Shai A3, Derazne E2, Tzur D1, Hershkovich O1,4, Afek A2.
Abstract
BACKGROUND AND OBJECTIVE:Asthma is associated with body mass index (BMI), but its association with socioeconomic status (SES) is controversial. The combined effect of SES and BMI on asthma prevalence is undetermined.
METHODS:Seventeen-year-old pre-recruits to the Israeli Defense Forces underwent routine physical examinations. SES was determined according to established criteria based on place of residence. The study population was divided according to classic weight groups and three SES groups (low, medium and high). Univariable and multivariable logistic regression models were applied to assess odds ratios (OR) of BMI and SES groups for asthma prevalence. The combined effect of BMI and SES was also calculated.
RESULTS:The 849 659 subjects included 480 993 males (9.5% asthma prevalence) and 368 666 females (6.7% asthma prevalence). Increased BMI were associated with increased OR for asthma in females (1.44, 95% CI 1.36-1.52 for obese vs normal weight). Males had a J-shaped curve (OR 1.24 95% CI 1.2-1.29 for obese, 1.12, 95% CI 1.08-1.16 for underweight, both vs normal weight). OR adjusted to SES did not change significantly. All SES groups produced a linear curve (1.59 95% CI 1.53-1.66 for females and 1.79 95% CI 1.74-1.84 for males). Adjustment of SES to BMI produced no significant change in OR. When all groups were compared with the normal weight/lower SES group, the highest OR was for the obese/higher SES group (2.32 95% CI 2.05-2.64 for females and 1.99 95% CI 1.83-2.13 for males).
CONCLUSIONS:Both BMI and SES are co-independently associated with asthma in adolescent males and females.
Respirology. 2015 Sep 22. doi: 10.1111/resp.12645. [Epub ahead of print]
