哮喘联盟

   摘要
   背景：焦虑和抑郁可能经常影响哮喘患者。然而，几项研究的结果部分是冲突的，而且是在选择过的队列进行研究。
   目的：探讨焦虑抑郁情绪对门诊哮喘患者的影响。
   方法：这是一项基于现实生活的横断面研究，包括263名哮喘患者（109名男性，平均年龄，39.2岁）。包括临床检查，肺功能，呼气一氧化氮测定，哮喘控制测试（ACT）评分，哮喘控制分级，视觉模拟量表测定感觉症状，医院焦虑和抑郁量表（HAD）问卷评估。
   结果：在全球范围内，97例（36.9%）有焦虑，29例（11%）有抑郁症。这些患者中，有71例合并焦虑和抑郁。焦虑和抑郁与哮喘控制不良相关（P值分别为0.007和0.02）。抑郁症患者的身体质量指数较高（P=.002）。焦虑和抑郁与较低的行为评分有明显的相关性（两项P<.001）。焦虑和抑郁与HADS分量表得分中度相关（r = 0.57）。
   结论：该项基于现实生活的研究表明，焦虑和抑郁是门诊哮喘患者常见的相关合并症，与哮喘控制不良和ACT分数较低相关。因此，对合并精神障碍的哮喘患者进行评估应列为日常诊疗行为。

 

（苏欣 审校）
AnnAllergyAsthmaImmunol.2015Sep18.pii:S1081-1206(15)00536-0.doi:10.1016/j.anai.2015.08.007. [Epub ahead of print]

 

The impact of anxiety and depression on outpatients with asthma.
 

Ciprandi G1, Schiavetti I2, Rindone E3, Ricciardolo FL3.
 

Abstract
BACKGROUND:Anxiety and depression may frequently affect patients with asthma. However, the findings of several studies are partially conflicting and conducted in selected cohorts.
OBJECTIVE:To investigate the effect of anxiety and depression in a group of outpatients with asthma.
METHODS:This cross-sectional, real-life study included 263 patients (109 males; mean age, 39.2 years) with asthma. Clinical examination, lung function, fractional exhaled nitric oxide measurement, Asthma Control Test (ACT) score, asthma control grade, perception of symptoms by visual analog scale, and Hospital Anxiety and Depression Scale (HADS) questionnaires were evaluated.
RESULTS:Globally, 97 patients (36.9%) had anxiety, and 29 (11%) had depression. Of these patients, 71 had combined anxiety and depression. Anxiety and depression were associated with poor asthma control (P =.007 and .02, respectively). Patients with depression had higher body mass indexes (P =.002). Anxiety and depression were associated with lower ACT scores (P < .001 for both). The scores on the anxiety and depression subscales of HADS were moderately related (r = 0.57).
CONCLUSIONS:The present real-life study indicates that anxiety and depression are common and relevant comorbidities in asthmatic outpatients and are associated with uncontrolled asthma and lower ACT scores. Thus, assessment of comorbid mental disorders should be performed in common practice.
 

AnnAllergyAsthmaImmunol.2015Sep18.pii:S1081-1206(15)00536-0.doi:10.1016/j.anai.2015.08.007. [Epub ahead of print]