哮喘联盟

   摘要
   慢性咳嗽是一个常见的医学问题。 本研究的目的旨在分析非吸烟患者慢性咳嗽的原因，并探寻不同咳嗽原因相关的人口统计学因素。咳嗽的病因由病史、诊断试验和对特殊治疗的反应决定。排除胸片或肺功能显著异常的患者。共131例非吸烟患者纳入研究；平均年龄为54岁，77%为女性。导致咳嗽发生最常见的原因是胃食管反流性疾病（GERD）（62%）和上呼吸道咳嗽综合征（UACS）（46%）。分别有32例（25%）和19例（15%）患者诊断为咳嗽变异性哮喘和非哮喘性嗜酸粒细胞性支气管炎（NAEB）。27例（32%）患者存在其他引起咳嗽的原因。女性哮喘患者比男性患者更易发生慢性咳嗽（女vs.男：31% vs.3%，p=0.005）。UACS在男女性患者中得到相反的结果（女vs.男：39%vs.67%，p=0.01）。50岁以上的慢性咳嗽患者更易存在不太常见的咳嗽原因。总之，最常见的慢性咳嗽原因为GERD和UACS。哮喘相关咳嗽更易发生在女性患者，UACS相关的咳嗽更易发生在男性。


 

（苏欣 审校）
Adv Exp Med Biol. 2015 Aug 19. [Epub ahead of print]

 

Causes of Chronic Cough in Non-smoking Patients.
 

DąbrowskaM1, GrabczakEM, ArcimowiczM, Domeracka-Kołodziej A, Domagała-Kulawik J, Krenke R, Maskey-Warzęchowska M, Tarchalska B, Chazan R.
 

Abstract
Chronic cough is a common medical problem. The aim of the study was to analyze chronic cough causes in non-smoking patients and to search for demographic factors associated with different cough reasons. The etiology of cough was determined by medical history, diagnostic tests and response to specific treatment. Patients with significant abnormalities in the chest radiograph or spirometry were not included. The study included 131 non-smoking patients; median age 54 years, 77 % female. The most frequent causes of cough were gastroesophageal reflux disease (GERD) (62 %) and upper airway cough syndrome (UACS) (46 %). Cough variant asthma and non-asthmatic eosinophilic bronchitis (NAEB) were diagnosed in 32 (25 %) and 19 (15 %) patients, respectively. Other cough causes were found in 27 patients (21 %). Asthma was a significantly more common cause of chronic cough in women than in men (31 % vs. 3 %, p = 0.005). A reverse relationship was demonstrated for UACS (39 % vs. 67 %, p = 0.01). Patients with chronic cough aged >50 yrs were more likely to be diagnosed with less common cough causes. In conclusion, the most common chronic cough reasons are GERD and UACS. Asthma-related cough is diagnosed more frequently in females, while UACS-related cough is more frequent in males.
 

Adv Exp Med Biol. 2015 Aug 19. [Epub ahead of print]