哮喘联盟

   摘要
   背景:膳食模式可能会影响波多黎各人哮喘的发病机制，波多黎各是美国最易受到哮喘疾影响的种族。
   目的:为了检验膳食，辅助型T细胞17型细胞因子和哮喘在波多黎各儿童中的相关性。
   方法:作为一项678例圣胡安6到14岁波多黎各儿童的病例对照研究的一部分，参与者完成了一份含75项条项目关于一周前儿童食物消耗的问卷。食物汇总为7大类：水果，蔬菜，谷物，蛋白质食物，乳制品，脂肪和甜食。采用Logistic 回归来评价每一类食物的消费频率，血浆辅助型T细胞17型细胞因子水平和哮喘的关系。基于这项分析，生成一项食物评分（范围从-2[不健康膳食：乳制品及甜食高消费，蔬菜及谷物低消费],到+2[健康膳食：谷物及蔬菜高消费，乳制品及甜食低消费]）以确定膳食模式。
   结果:谷物高消费是与哮喘的低比率相关的 (调整后的OR值 [aOR] 为0.52, 95% 置信区间 [CI] 0.33-0.82), 然而乳制品 (aOR 1.93, 95% CI 1.32-2.84) 或甜食(aOR 1.82, 95% CI 1.08-2.72) 的消费频率是与哮喘的高比率相关的。更健康的膳食(食物评分每增加1)是与白介素-17较低水平 (β = -1.48 pg/mL, 95% CI -1.78 to -1.20) 以及哮喘降低36%比率相关 (aOR 0.64, 95% CI 0.53-0.77).
   结论:含有较高频率蔬菜及谷物消费，较低频率乳制品及甜食消费的健康膳食，与白介素-17水平较低，以及波多黎各儿童哮喘比率减少相关。

 

（苏欣 审校）
AnnAllergyAsthmaImmunol. 2015Aug26.pii:S1081-1206(15)00517-7.doi:10.1016/j.anai.2015.07.020. [Epub ahead of print]
 

Diet, interleukin-17, and childhood asthma in Puerto Ricans.
 

Han YY1, Forno E2, Brehm JM1, Acosta-Pérez E3, Alvarez M3, Colón-Semidey A3, Rivera-Soto W4, Campos H5, Litonjua AA6, Alcorn JF1, Canino G3,Celedón JC1.
 

Abstract
BACKGROUND:Dietary patterns might influence the pathogenesis of asthma in Puerto Ricans, the ethnic group most affected by this disease in the United States.
OBJECTIVE:To examine the association among diet, T-helper cell type 17 cytokines, and asthma in Puerto Rican children.
METHODS:As part of a case-control study of 678 Puerto Rican children 6 to 14 years old in San Juan, participants completed a 75-item questionnaire on the child's food consumption in the prior week. Foods were aggregated into 7 groups: fruits, vegetables, grains, protein foods, dairy, fats, and sweets. Logistic regression was used to evaluate consumption frequency of each group, plasma T-helper cell type 17 cytokine levels, and asthma. Based on this analysis, a food score (range -2 [unhealthy diet: high consumption of dairy products and sweets, low consumption of vegetables and grains] to +2 [healthy diet: high consumption of grains and vegetables, low consumption of dairy and sweets]) was created to identify dietary patterns.
RESULTS:High consumption of grains was associated with lower odds of asthma (adjusted odds ratio [aOR] 0.52, 95% confidence interval [CI] 0.33-0.82), whereas frequent consumption of dairy products (aOR 1.93, 95% CI 1.32-2.84) or sweets (aOR 1.82, 95% CI 1.08-2.72) was associated with higher odds of asthma. A healthier diet (each 1-point increment in food score) was associated with lower levels of interleukin-17F (β = -1.48 pg/mL, 95% CI -1.78 to -1.20) and with 36% decreased odds of asthma (aOR 0.64, 95% CI 0.53-0.77).
CONCLUSION:A healthy diet, with frequent consumption of vegetables and grains and low consumption of dairy products and sweets, was associated with lower levels of interleulin-17F and decreased odds of childhood asthma in Puerto Ricans.
 

AnnAllergyAsthmaImmunol. 2015Aug26.pii:S1081-1206(15)00517-7.doi:10.1016/j.anai.2015.07.020. [Epub ahead of print]