哮喘联盟

   摘要
   研究背景：哮喘流行病学研究已有数十年，尽管发布了众多的专家观点，尚缺乏一种系统评价来阐述此领域已经取得的成果和存在哪些知识缺口。
   研究方法：通过在MEDLINE 和 EMBASE上进行截止到201412月的系统的文献检索，首次完成了一篇在变态反应流行病学领域的系统评价。本评述包括系统的文献检索，阐明发病率、患病率、时间趋势或一些过敏性疾病的分险/保护因子。在干预方法中只纳入一级预防，排除二级或三级预防干预。本研究进行了哮喘或喘息的系统评价，其它方面包括研究主题的提取，和应用AMSTAR方法评价系统评价的质量。
   研究结果：此研究检索到4566篇，其中411篇相关，75%与哮喘或喘鸣有关。这些文章在1997年和2015年期间发表(中位数2011年)。AMSTAR评分均数是8(Q1=5,Q3=9)。近几年有轻微的增加。最常研究的点是遗传(约27%)，其次是污染物（16%包括吸烟），微生物(14%)和体重及饮食（各12%）。然而28%明确研究的是儿童，仅有4%集中于成人哮喘。
   研究结论：尽管一些方法学的局限性，已经发表了很多有关哮喘流行病学系统评价，有关哮喘遗传，吸烟，体重相关的内容已经有充分的研究证据，而其他方面，可能由于缺乏原始数据而缺乏系统评价。

 

（南方医科大学南方医院 王燕红 赵海金 ）
2015,ERS Meeting
 

The state of asthma epidemiology - An overview of systematic reviews    
 
Annina M. Seibold¹, Jon Genuneit¹
¹Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
2015,ERS Meeting
PA5076 http://abstract.ersnet.org/my-abstract-book-2015/     

Abstract    
Background: Epidemiological research on asthma has been conducted for decades. While numerous expert opinion publications exist, there is no systematic overview over what this field of research has achieved and which knowledge gaps may exist.
Methods: We performed to our knowledge the first overview of systematic reviews in allergy epidemiology conducting a systematic literature search in MEDLINE and EMBASE up to 12/2014. We included reviews indicating a systematic literature search and dealing with incidence, prevalence, time trends, or risk/protective factors for several allergic diseases. Interventions for primary prevention were included, interventions for secondary or tertiary prevention were excluded. Here, we describe systematic reviews dealing with asthma or wheeze. Amongst other indicators the topic of research was extracted and quality was evaluated using the AMSTAR checklist (ongoing; n=231 and n=94, respectively).
Results: The search retrieved 4,566 hits of which 411 were relevant with 75% on asthma or wheeze. They were published between 1997 and 2015 (median 2011); median AMSTAR score was 8 (Q1=5, Q3=9) with slightly increasing quality in more recent years. The topic most often studied was genetics (27% of the reviews), followed by pollution (16% including smoking), microbes (14%), and body weight and diet (each 12%). Whereas 28% investigated specifically childhood, only 4% focused on adult asthma.
Conclusion: Numerous systematic reviews in asthma epidemiology have been published although some have limited methodological quality. Substantial evidence has been gathered for genetics, smoking, and body weight but other research topics lack systematic reviews, potentially due to a lack of original data.