哮喘联盟

   摘要
   目的：综合世界性研究旨在验证两种假设：(i)与大多数人比较，躁郁症与吸烟行为有关；(ii)躁郁症患者的吸烟率介于重度抑郁症患者和精神分裂症患者之间。
   方法：通过PubMed搜索或收集资深作者的文章，共56篇有关成人的研究纳入分析。采用比值比(ORs)和95%可信区间(CIs)比较了躁郁症患者和对照组的当前吸烟情况、现在吸烟者中重度吸烟情况、曾经吸烟者的戒烟情况和曾经吸烟情况。
   结果：来自16个国家51项最近的吸烟研究的综合分析表明，躁郁症患者与正常人群相比吸烟比值比为3.5 (CI: 3.39-3.54)。更多有限的数据分析得到戒烟人群的OR值 为 0.34 (CI: 0.31-0.37)和曾经吸烟人群的OR值为3.6 (CI: 3.30-3.80)。来自10个国家20项研究的综合分析表明与精神分裂症患者相比，躁郁症患者的现在吸烟的OR 值为 0.76 (CI: 0.74-0.79)。躁郁症患者曾经吸烟率低于精神分裂症患者(OR = 0.83, CI: 0.75-0.91)。来自7个国家18项研究的综合分析表明与重度抑郁症患者比较，躁郁症患者的当前吸烟OR为 2.05 (CI: 2.00-2.10)。与重度抑郁症患者相比，躁郁症患者的曾经吸烟率高(OR = 1.5, CI: 1.40-1.70)、戒烟率低(OR = 0.51, CI: 0.45-0.59)。
   结论：与普通人群相比，躁郁症患者增加的当前吸烟率反映了高曾经吸烟率（起始）和低戒烟率。躁郁症患者的吸烟行为频率可能在抑郁症患者和精神分裂症患者之间，因为精神分裂症患者吸烟频率最高。


 

（苏欣 审校）
Bipolar Disord. 2015 Aug 4. doi: 10.1111/bdi.12319. [Epub ahead of print]


 

A combined analysis of worldwide studies demonstrates an association between bipolar disorder and tobacco smoking behaviors in adults.
 

Jackson JG1, Diaz FJ2, Lopez L3, de Leon J4,5,6.
 

Abstract
OBJECTIVES:Worldwide studies were combined to examine two hypotheses: (i) bipolar disorder is associated with smoking behaviors, compared with the general population; and (ii) smoking behavior prevalences in bipolar disorder are intermediate between those in major depressive disorder and those in schizophrenia.
METHODS:Combined analyses used 56 articles on adults obtained from a PubMed search or the senior author's article collection. Odds ratios (ORs) and their 95% confidence intervals (CIs) compared current smoking, heavy smoking among current smokers, smoking cessation in ever smokers, and ever smoking in bipolar disorder versus control groups.
RESULTS:The combined OR was 3.5 (CI: 3.39-3.54) in 51 current smoking studies of bipolar disorder versus the general population from 16 countries. More limited data provided an OR = 0.34 (CI: 0.31-0.37) for smoking cessation and an OR = 3.6 (CI: 3.30-3.80) for ever smoking. The combined OR was 0.76 (CI: 0.74-0.79) for current smoking in bipolar disorder versus schizophrenia in 20 studies from ten countries. Ever smoking may be lower in bipolar disorder than in schizophrenia (OR = 0.83, CI: 0.75-0.91). The OR was 2.05 (CI: 2.00-2.10) for current smoking in bipolar disorder versus major depression in 18 studies from seven countries. Ever smoking may be higher (OR = 1.5, CI: 1.40-1.70) and smoking cessation lower (OR = 0.51, CI: 0.45-0.59) in bipolar disorder than in major depression。
CONCLUSIONS:Increased current smoking in bipolar disorder versus the general population reflected increased ever smoking (initiation) and decreased smoking cessation. Smoking behavior frequencies in bipolar disorder may be between those in depressive disorder and schizophrenia, with schizophrenia showing the highest severity level.
 

Bipolar Disord. 2015 Aug 4. doi: 10.1111/bdi.12319. [Epub ahead of print]