吸烟、戒烟和牙齿缺失的风险：EPIC-波茨坦研究
2015/10/23
摘要
本研究旨在通过一个在德国进行的大样本队列研究探讨吸烟，戒烟与牙齿缺失患病率和发病率之间的关系。我们对1994年到1998年间欧洲癌症和营养前瞻性调查（EPIC）-波茨坦研究纳入的23376例完成吸烟、戒烟和协变量调查的受试者的数据进行了分析，这些受试者主要来自波茨坦，其余来自德国的勃兰登堡。在随访中分别用负二项回归模型和牙齿特异逻辑回归模型来评估随访过程中吸烟和牙齿缺失基线患病率和基线发病率之间的相关性。在随访中发现吸烟和牙齿缺失高患病率和高发病率相关。吸烟和牙齿缺失发病率之间的相关性男性强于女性、年轻个体强于老年个体。与不吸烟者比较，50岁以下男性重度吸烟者（≥15支/天）牙齿缺失风险增加3倍以上(比值比, 3.6; 95% 可信区间, 3.0, 4.4)，50岁以下女性风险增加2倍以上（比值比，2.5; 95% 可信区间, 2.1, 2.9)。戒烟与降低的牙齿缺失风险显著相关，当戒烟约10-20年后牙齿缺失风险与不吸烟者相当。
（苏欣 审校）
J Dent Res. 2015 Aug 4. pii: 0022034515598961. [Epub ahead of print]
Smoking, Smoking Cessation, and Risk of Tooth Loss: The EPIC-Potsdam Study.
Dietrich T1, Walter C2, Oluwagbemigun K3, Bergmann M3, Pischon T3, Pischon N4, Boeing H3.
Abstract
The aim of this study was to investigate the association between cigarette smoking and smoking cessation and the prevalence and incidence of tooth loss in a large cohort study in Germany. We analyzed data of 23,376 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study recruited between 1994 and 1998 from the general population in Potsdam and other parts of Brandenburg, Germany, who had complete data on cigarette smoking, tooth loss, and covariates. Negative binomial regression and tooth-specific logistic regression models were fit to evaluate the association between smoking and the baseline prevalence and incidence of tooth loss during follow-up, respectively. Cigarette smoking was associated with higher prevalence of tooth loss at baseline as well as higher incidence of tooth loss during follow-up. The association between smoking and the incidence of tooth loss was stronger in men than women and stronger in younger versus older individuals. Heavy smoking (≥15 cigarettes/d) was associated with >3 times higher risk of tooth loss in men (odds ratio, 3.6; 95% confidence interval, 3.0, 4.4) and more than twice the risk of tooth loss in women (odds ratio, 2.5; 95% confidence interval, 2.1, 2.9) younger than 50 y when compared with never smokers. Smoking cessation was consistently associated with a reduction in tooth loss risk, with the risk of tooth loss approaching that of never smokers after approximately 10 to 20 y of cessation.
J Dent Res. 2015 Aug 4. pii: 0022034515598961. [Epub ahead of print]
