哮喘联盟

   摘要
   多配体聚糖-4 (SDC4) 在树突细胞(DCs)和活化的T细胞中表达。多配体聚糖-4在DC的运动中发挥关键作用，可作为活化T细胞性疾病的潜在靶点。在本研究中，我们调查了SDC4在Th2细胞介导的过敏性哮喘发展中的作用。使用了SDC4缺陷性小鼠或抗SDC4抗体，结果显示：相对于对照动物，卵白蛋白敏感小鼠中的SDC4 信号的缺乏或抑制会导致哮喘表型的降低。更重要的是，抗SDC4抗体甚至能显著减少建立的哮喘。干扰SDC4信号会导致抗原呈递DCs运动和定向迁移受损，从而导致敏感性的改变，进而导致气道炎症的减弱。我们的结果表明SDC4在哮喘发生中发挥重要作用，SDC4可作为哮喘治疗干预的一个可能靶点。
 

（苏欣 审校）
Nat Commun. 2015 Jul 13;6:7554. doi: 10.1038/ncomms8554.

 

Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
 

Polte T1, Petzold S1, Bertrand J2, Schütze N3, Hinz D4, Simon JC5, Lehmann I6, Echtermeyer F7, Pap T2, Averbeck M5.
 

Abstract
Syndecan-4 (SDC4), expressed on dendritic cells (DCs) and activated T cells, plays a crucial role in DC motility and has been shown as a potential target for activated T-cell-driven diseases. In the present study, we investigate the role of SDC4 in the development of T-helper 2 cell-mediated allergic asthma. Using SDC4-deficient mice or an anti-SDC4 antibody we show that the absence or blocking of SDC4 signalling in ovalbumin-sensitized mice results in a reduced asthma phenotype compared with control animals. Most importantly, even established asthma is significantly decreased using the anti-SDC4 antibody. The disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting DCs and therefore, to a modified sensitization leading to diminished airway inflammation. Our results demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as possible target for therapeutic intervention in this disease.
 

Nat Commun. 2015 Jul 13;6:7554. doi: 10.1038/ncomms8554.