哮喘联盟

   摘要
   目的：探讨哮喘患儿体重指数(BMI)及血清炎性因子水平对哮喘控制的影响。
   方法：依据BMI 结果将2013年1月至2014年5月收治的116 例哮喘患儿分为正常组(n=59)、消瘦组(n=31)与肥胖组(n=26),ELISA 法检测各组患儿白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平,免疫比浊法检测各组高敏C 反应蛋白(hs-CRP)水平。治疗4 周后采用儿童哮喘控制测试(C-ACT)评价各组患儿哮喘控制情况。
   结果：IL-6、hs-CRP 及TNF-α 在正常组、消瘦组及肥胖组水平依次增加(PPPP>0.05);IL-6、hs-CRP 及TNF-α 与C-ACT 评分均呈负相关(PP>0.05)。
   结论：BMI 过高或过低时,血清炎性因子水平均升高,不利于哮喘控制,哮喘患儿维持正常体重有利于降低血清炎性因子水平,提高哮喘控制率。
 

（杨冬 审校）
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jul;17(7):698-701.
 

Effects of body mass index and serum inflammatory cytokines on asthma control in children with asthma.
 

[Article in Chinese]
Chen XJ1, Zhang YH, Wang DH, Liu YL.
 

Abstract
OBJECTIVE:To explore the effects of body mass index (BMI) and the levels of serum inflammatory cytokines on asthma control in children with asthma.
METHODS:One hundred and sixteen children with asthma were divided into three groups: normal (n=59), thin (n=31), and obesity (n=26) based on their BMI. The levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were determined using ELISA, and the level of high-sensitivity C-reactive protein (hs-CRP) was measured by immunoturbidimetric assays. Asthma control status in each group was evaluated by the Childhood Asthma Control Test (C-ACT) after 4 weeks of treatment.
RESULTS:The serum levels of IL-6, hs-CRP, and TNF-α were highest in the obesity group, followed by the thin group and the normal group (P<0.05), while the C-ACT score was highest in the normal group, followed by the thin group and obesity group (P<0.05). The normal group had significantly higher complete controlled and partially controlled rates than the thin and obesity groups (P<0.05); however, there were no significant differences between the thin and obesity groups (P>0.05). The levels of IL-6, hs-CRP, and TNF-α were negatively correlated with the C-ACT score (P<0.05). There were no significant correlations of BMI with the C-ACT score and levels of IL-6, hs-CRP, and TNF-α (P>0.05).
CONCLUSIONS:When BMI is too high or too low, the levels of serum inflammatory cytokines are all increased, which is harmful to asthma control. Maintaining a healthy weight in children with asthma may reduce the levels of serum inflammatory cytokines and improve the asthma control rate.
 

Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jul;17(7):698-701.