基于人群的病例对照研究：他汀类药物使用与膀胱疼痛综合征/间质性膀胱炎有关
2015/09/07
摘要
介绍：他汀类药物能诱发膀胱上皮功能障碍。上皮功能障碍被认为是膀胱疼痛综合征/间质性膀胱炎（BPS/IC）的主要潜在病因之一。本人群研究探究他汀类药物的使用与BPS/IC的关系。
对象和方法：本次病例对照研究采用台湾纵向健康保险数据。总计815名患有BPS/IC的女性作为研究组，4075名随机的女性作为对照组纳入研究。采用条件logistic回归计算病例组与对照组之间先前使用他汀类药物的优势比(OR)。
结果：条件logistic回归分析显示，在校正糖尿病、高血压、冠心病、肥胖、慢性骨盆痛、肠易激综合征、纤维肌痛、慢性疲劳综合症、抑郁、惊恐性障碍、偏头痛、干燥综合征、过敏、子宫内膜异位和哮喘后，病例组相较于对照组先前使用过他汀类药物的的OR值为1.52 (95% 置信区间 (CI): 1.19-1.94) 。病例组相较于对照组，规律和非规律使用他汀类药物的校正OR值分别为58 (95% CI: 1.20-2.08) 和 1.53 (95% CI: 1.02-2.31)。
结论：他汀类药物使用与BPS/IC有关。
（杨冬 审校）
Urol Int. 2015 Jul 16. [Epub ahead of print]
Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study.
Huang CY1, Chung SD, Kao LT, Lin HC, Wang LH.
Abstract
INTRODUCTION:Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study.
SUBJECTS AND METHODS:This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls.
RESULTS:A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls.
CONCLUSION:We concluded that there was an association between statin use and BPS/IC.
Urol Int. 2015 Jul 16. [Epub ahead of print]
