哮喘联盟

   摘要
   加拿大健康婴儿纵向发育（CHILD）出生队列研究招募了3624名孕妇、大部分伴侣和3542名符合条件的后代。我们假定：生命早期的生理和心理环境、免疫因素、生理因素、营养因素、激素和代谢因素会与遗传因素相互作用进而影响过敏性疾病，包括哮喘。对环境和生物样本、先天和适应性免疫反应、基因表达、DNA甲基化、肠道微生物和营养进行研究直至患儿5岁，以补充重复的环境和临床评估。这个丰富的数据集将产前和产后的环境、不同的生物样品与严格的表型联系了起来，并将告知过敏、哮喘和其他慢性炎症性疾病的早期发育途径。
 

（杨冬 审校）
Thorax. 2015 Jun 11.pii:thoraxjnl-2015-207246.doi:10.1136/thoraxjnl-2015-207246. [Epub ahead of print]

 

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
 

Subbarao P1, Anand SS2, Becker AB3, Befus AD4, Brauer M5, Brook JR6, Denburg JA2, HayGlass KT3, Kobor MS5,Kollmann TR5, Kozyrskyj AL4, Lou WY7, Mandhane PJ4, Miller GE8, Moraes TJ1, Pare PD5, Scott JA7, Takaro TK9,Turvey SE5, Duncan JM2, Lefebvre DL2, Sears MR2; CHILD Study investigators.
 

Abstract
The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.
 

Thorax. 2015 Jun 11.pii:thoraxjnl-2015-207246.doi:10.1136/thoraxjnl-2015-207246. [Epub ahead of print]