哮喘联盟

   摘要
   背景:既往研究有假设睡眠呼吸障碍 (SDB)可能与哮喘的发生和急性发作相关。然而，这一假设证据有限。本研究旨在研究哮喘的患病率和易发因素， 以及量化中国学龄儿童中 SDB和哮喘的相关性。另外，一项已公布证据和我们研究结果的全面荟萃分析进一步进行。
   方法:为了证实这一假设, 我们进行了一项多中心性的横断面研究，纳入22,478名来自中国8个城市的5-12岁儿童。而且，我们将先前发表的多项研究和我们的横断面研究结果进行了一项荟萃分析。
   结果:在我们的横断面研究样本中，SDB和哮喘的患病率分别是12.0% 和 3.5%. 经证明，在调整了潜在的混杂因素后，SDB的症状如习惯性打鼾(优势比（OR）=1.28, 95%CI: 1.01-1.62), 阻塞性睡眠呼吸暂停 (OSA) (OR=1.92, 95%CI: 1.34-2.76)与哮喘是显著相关的。 在荟萃分析中, SDB与哮喘患病率相关，不论是儿童 (优势比为 1.58, 95%CI: 1.35-1.80) 还是成人 (优势比为1.55, 95%CI: 1.42-1.67).
   结论:我们的研究提供了在 SDB 和哮喘之间的存在独立关联的进一步证据。临床意义在于对接受哮喘检查或治疗的儿童应当加强睡眠问题的常规筛查。对于潜在的机制的阐述需要进一步的系统研究。

（杨冬 审校）
Respir Res. 2015 May 10;16(1):56. [Epub ahead of print]

 

Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China.
 

Li L1,2, Xu Z3, Jin X4, Yan C5, Jiang F6, Tong S7, Shen X8, Li S9,10.

Author information
 

Abstract
BACKGROUND:Previous studies have postulated that sleep-disordered breathing (SDB) may be associated with the occurrence and exacerbation of asthma. However, there was limited quantitative evidence on the topic. This study aimed at investigating the prevalence and predisposing factors of asthma, and quantifying the association between SDB and asthma among school-aged children in China. In addition, a comprehensive meta-analysis of the published evidences and our findings were further conducted.
METHODS:To test the hypothesis, we conducted a multicentric cross-sectional study involving 22,478 children aged 5-12 years recruited from eight cities in China. Furthermore, a meta-analysis based on both previously published studies and our cross-sectional study was performed.
RESULTS:The prevalence rate of SDB and asthma was 12.0% and 3.5% among our cross-sectional study sample. It was demonstrated that symptoms of SDB, such as habitual snoring (OR = 1.28, 95%CI: 1.01-1.62), and obstructive sleep apnea (OSA) (OR = 1.92, 95%CI: 1.34-2.76), were significantly associated with asthma, after adjusting for potential confounding factors. In the meta-analysis, SDB was correlated with the prevalence of asthma in both children (OR = 1.58, 95%CI: 1.35-1.80) and adults (OR = 1.55, 95%CI: 1.42-1.67).
CONCLUSIONS:Our results provide further evidence for the independent association between SDB andasthma. The clinical significance of our findings lies in the emphasis that children undergoing examination or treatment for asthma should be routinely screened for sleep problems. Further systematic study is required to illuminate the underlying mechanism.
 

Respir Res. 2015 May 10;16(1):56. [Epub ahead of print]