哮喘联盟

   摘要
   背景：职业相关性哮喘的发生较普遍，并且其诊断仍具有一定挑战性。列举一系列与职业相关性哮喘有关的因素对帮助其诊断有一定价值。
   方法：劳动与环境卫生协会（AOEC）对同行评议的医学英语文献回顾性分析制定了相关标准。根据该回顾性分析的结果，相关物质被分为致敏剂或刺激物。此次回顾性分析由2002－2007年间有专业证书的内科医生/呼吸内科医生/职业病学专家以及2008－至今有专业证书的内科医生/职业病医师执行。所有的综述由AOEC理事会的9个成员评阅。
   结果：最初的与新发职业相关性哮喘相关因素列表源自职业相关性哮喘教科书的表格里。经过13年的回顾性分析，总共有327种物质被AOEC列入哮喘相关性因素。其中173种（52.9%）为致敏剂，35种（10.7%）通常作为哮喘引发剂，4种（1.2%）为刺激剂，2种（0.6%）既是致敏剂又是刺激剂，113种（34.6%）仍需评估。
   结论：AOEC在网站上列举了一系列与新发成人职业相关性哮喘有关的因素。该列表中的内容基于同行专家评议的标准，且内容每年更新两次。他们定期地对同行专家发表的医学文献进行回顾性分析，以确定是否应该在列表中添加新的物质。该列表在临床医生考虑诊断职业相关性哮喘时应有较大作用。

（杨冬 审校）
Respir Med. 2015 Mar31.pii:S0954-6111(15)00103-1.doi:10.1016/j.rmed.2015.03.004. [Epub ahead of print]
 

Web based listing of agents associated with new onset work-related asthma.
 

Rosenman KD1, Beckett WS2.

Author information
 

Abstract
BACKGROUND:Work-related asthma is common and yet remains a challenge to diagnose. Access to a listing of agents associated with work-related asthma has been suggested as useful in assisting in the diagnosis.
METHODS:The Association of Occupational and Environmental Clinics (AOEC) developed criteria that were used to review the peer-reviewed medical literature published in English. Based on this review, substances were designated either as a sensitizing agent or an irritant. The reviews were conducted by a board certified internist/pulmonologist/occupational medicine specialist from 2002 to 2007 and a board certified internist/occupational medicine physician from 2008- date. All reviews were then reviewed by the nine member AOEC board of directors.
RESULTS:The original list of agents associated with new onset work-related asthma was derived from the tables of a text book on work-related asthma. After 13 years of review, there are 327 substances designated as asthma agents on the AOEC list; 173 (52.9%) coded as sensitizers, 35 (10.7%) as generally recognized as an asthma causing agent, four (1.2%) as irritants, two (0.6%) as both a sensitizer and an irritant and 113(34.6%) agents that still need to be reviewed.
CONCLUSIONS:The AOEC has developed a readily available web based listing of agents associated with new onset work-related asthma in adults. The listing is based on peer-reviewed criteria. The listing is updated twice a year. Regular review of the peer-reviewed medical literature is conducted to determine whether new substances should be added to the list. Clinicians should find the list useful when considering the diagnosis of work-related asthma.
 

Respir Med. 2015 Mar31.pii:S0954-6111(15)00103-1.doi:10.1016/j.rmed.2015.03.004. [Epub ahead of print]