哮喘联盟

   摘要
   对于独生子，通常认为哮喘可能与儿童身高偏低以及青春期发育迟缓相关。但是，那些研究并没有排除遗传对哮喘、青春期/初潮以及身高的影响。本项目旨在针对异性双胞胎群体以及同性双胞胎群体（不同哮喘症状），研究哮喘与男孩青春期和身高、以及女孩初潮和身高之间的关联。研究收集瑞典双胞胎及父母或哮喘患者自身对哮喘症状的阐述，记录男孩青春期来临时间和女孩初潮时间，以及身高等。通过Petersen指数对青春期进行分期。通过逻辑和线性回归分析评估哮喘与青春期来临时间/初潮时间，以及患者身高之间的关联性。对于不同哮喘症状的双胞胎群体，采用条件逻辑和线性回归法进行分析。研究共纳入2,658例双胞胎（其中49.1%为男孩）。对于男孩，8～9岁时哮喘发病率为8.2%，13～14岁时哮喘发病率为10.2%。而相同年龄段的女孩哮喘发病率分别为4.2%和4.9%。在不考虑性别因素的前提下，哮喘与男孩青春期来临时间和女孩初潮时间之间无显著关联性。对于8～9岁和13～14岁的男孩，患有哮喘的男孩较无哮喘的男孩更矮（其平均身高分别为1.86 [0.17-3.56] cm和2.94 [0.98-4.91] cm，概率分别为0.03和0.003）。但是，对于19～20岁的男孩，患有哮喘和无哮喘的群体间身高无统计学差异。对于女孩，哮喘与其身高无显著关联性。对于同性的双胞胎群体（不同哮喘症状），无论男孩还是女孩，哮喘与身高均无显著关联。患有哮喘的男性双胞胎较无哮喘的更矮，但是，女孩则无显著差异。双胞胎配对分析的非统计学差异结果表明，这种关联性可能混杂了部分遗传因素或家庭环境因素。
 

（苏欣 审校）
Twin Res Hum Genet. 2015 Mar 12:1-9. [Epub ahead of print]

 

Asthma and Height in Twins: A Cohort and Within-Pair Analyses Study.
 

Protudjer JL1, Lundholm C1, Almqvist C1.

Author information
 

ABSTRACT
In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study the association between asthma and puberty in boys and menarche in girls, and height, in a cohort of twins and subsequently in same-sex twin pairs discordant for asthma. From a Swedish twin cohort, parent- and self-reported data on asthma, puberty/menarche, and height were collected. Pubertal staging was established via the Petersen index. Logistic and linear regression was used to estimate associations between asthma and puberty/menarche and height, respectively. For within-pair analyses in twins discordant for asthma, conditional logistic and linear regression were used. Data on 2,658 (49.1% boys) twins were included. Among boys, asthma prevalence was 8.2% at 8-9 years and 10.2% at 13-14 years. Corresponding numbers for girls were 4.2% and 4.9%, respectively. In the entire cohort, no statistically significant associations were found between current asthma and puberty/menarche. Boys with asthma were shorter than boys without asthma at 8-9 years (on average, 1.86 [0.17-3.56] cm, p = .03) and at 13-14 years (on average, 2.94 [0.98-4.91] cm, p = .003) but not at 19-20 years. No such associations were found for girls. Within same-sex twin pairs discordant for asthma, no statistically significant associations were found for either sex. Twin boys, but not girls, with asthma were shorter than those without asthma. Non-statistically significant estimates from within-pair analyses suggest the association is partly confounded by genetic or familial environmental factors.
 

Twin Res Hum Genet. 2015 Mar 12:1-9. [Epub ahead of print]