儿童出生前后父母患过敏性疾病可使儿童时期患过敏性疾病有同样风险
2015/05/22
摘要
亲代与子代过敏性疾病之间的关联性是否因亲代过敏性疾病初发于子代分娩前或分娩后而不同尚未被研究，这也是本研究的目的。研究使用广义估计方程对每年诊断为哮喘、过敏性鼻炎以及湿疹的儿童与其父母的相同类型的疾病（发生于孩子生产前或生产后）分别进行纵向回归分析。小于15岁哮喘儿童疾病的发生与母亲和父亲的哮喘发病史均相关。无论父母亲的哮喘初发于孩子生产前还是生产后，其与孩子哮喘发生的关联性相似。但对于过敏性鼻炎和湿疹，两者之间的关联性具有一定区别。本研究的结果显示，亲代患有过敏性疾病（无论初发于孩子生产前或生产后）会增加子代儿童时期的过敏性疾病，尤其是哮喘的发生风险。
（杨冬 审校）
Allergy. 2015 Mar 13. doi: 10.1111/all.12609. [Epub ahead of print]
Parental allergic disease before and after child birth poses similar risk for childhood allergies.
Fuertes E1, Standl M, von Berg A, Lehmann I, Hoffman B, Bauer CP, Koletzko S, Berdel D, Heinrich J.
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ABSTRACT
Whether the strength of associations between parental and child allergic diseases differs by whether the first onset of the parental disease is before or after a child's birth has never been examined and is the aim of this study. Yearly childhood asthma, allergic rhinitis and eczema diagnoses were longitudinally regressed against the effect of a parental disease (pre versus post child birth) of the same type separately for each parent using generalized estimation equations. Both a maternal and paternal history of asthma were associated with childhood asthma prevalence up to 15 years of age. Effect estimates were similar for parental asthma with first onset before and after the birth of the child. The results for allergic rhinitis and eczema were less consistent. Parental allergic diseases with first onsets before and after the birth of a child both pose risks to childhood allergic disease in the offspring, especially for asthma. This article is protected by copyright. All rights reserved.
Allergy. 2015 Mar 13. doi: 10.1111/all.12609. [Epub ahead of print]
