哮喘联盟

   摘要
   背景：对于哮喘与强直性脊柱炎（AS）之间的关联性向来存在争议。本研究旨在调查全国范围内强直性脊柱炎患者发生哮喘的风险。
   方法：我们采用台湾国民健康保险（NHI）系统中的数据进行回顾性队列研究。本研究总共纳入了2000～2010年间首次被诊断为强直性脊柱炎的5,974例患者。将诊断日期设定为试验开始的时间。同时，随机选择4倍数量的非强直性脊柱炎个体与实验组患者的年龄、性别以及发病时间配对。在2011年底评估所有研究群体哮喘的发生率和危害比（HR）。
   结果：强直性脊柱炎患者组哮喘的总发生率比非强直性脊柱炎组高1.74倍（发病率分别为8.26/1000人年和4.74/1000人-年），多变量Cox法校正后的危害比为1.54（95%可信区间为1.34－1.76）。同时，在强直性脊柱炎患者组，女性患者校正后的危害比高于男性（危害比为1.59；95%可信区间为1.33－1.90），50～64岁年龄组患者校正后的危害比高于其它年龄组患者（危害比为1.66；95%可信区间为1.31－2.09），没有并发症组患者校正后的危害比高于有并发症患者（危害比为1.82；95%可信区间为1.54－2.13）。
   结论：在不考虑性别和年龄因素的前提下，强直性脊柱炎患者哮喘发生的风险仍高于普通人群。其病理生理学机制需要进一步的研究。
 

（杨冬 审校）
PLoS One. 2015 Feb 6;10(2):e0116608. doi: 10.1371/journal.pone.0116608.eCollection 2015.

 

The risk of asthma in patients with ankylosing spondylitis: a population-based cohort study.
 

Shen TC1, Lin CL2, Wei CC3, Chen CH1, Tu CY4, Hsia TC4, Shih CM4, Hsu WH4, Sung FC5.
 

ABSTRACT
BACKGROUND: The relationship between asthma and ankylosing spondylitis (AS) is controversial. We examined the risk of asthma among AS patients in a nationwide population.
METHODS: We conducted a retrospective cohort study using data from the National Health Insurance (NHI) system of Taiwan. The cohort included 5,974 patients newly diagnosed with AS from 2000 to 2010. The date of diagnosis was defined as the index date. A 4-fold of general population without AS was randomly selected frequency matched by age, gender and the index year. The occurrence and hazard ratio (HR) of asthma were estimated by the end of 2011.
RESULTS: The overall incidence of asthma was 1.74 folds greater in the AS cohort than in the non-AS cohort (8.26 versus 4.74 per 1000 person-years) with a multivariable Cox method measured adjusted HR of 1.54 (95% confidence interval (CI), 1.34-1.76). The adjusted HR of asthma associated with AS was higher in women (1.59; 95% CI, 1.33-1.90), those aged 50-64 years (1.66; 95% CI, 1.31-2.09), or those without comorbidities (1.82; 95% CI, 1.54-2.13).
CONCLUSION: Patients with AS are at a higher risk of developing asthma than the general population, regardless of gender and age. The pathophysiology needs further investigation.
 

PLoS One. 2015 Feb 6;10(2):e0116608. doi: 10.1371/journal.pone.0116608.eCollection 2015.