哮喘联盟

   摘要
   背景：低出生体重和婴儿期的迅速生长与儿童哮喘风险的增加息息相关，但鲜为人知的是婴儿期后生长对哮喘患儿的作用。
   目的：我们寻求调查儿童生长模式与青春期哮喘、支气管反应性、肺功能的关联。
   方法：9723名儿童参加了这项以人群为基础的前瞻性队列研究，利用多线性样条模型估计他们从出生直到10岁的个体生长轨迹。提供调查问卷了解他们8、14和17岁时的哮喘情况。通过就诊期间的测定数据了解他们8和15岁时的肺功能和气道反应性或可逆性。
   结果：0～3个月期间快速的体重增加与8岁和17岁罹患哮喘风险增加、8岁气道反应性高及15岁气道可逆性差有相关性。体重快速增加与肺功能值相关，这种相关性在以下情况最显著：3～7岁体重增加和15岁时较高的用力肺活量（FVC）值和FEV1值(z评分/SD分别为0.12 [95% CI, 0.08 ～0.17]和0.11 [95% CI, 0.07～0.15])的相关性，0～3个月体重增长和8岁、15岁时较低的FVC1/FVC值(z评分/SD分别为-0.13 [95% CI, -0.16 ～ -0.10] 和-0.04 [95% CI, -0.07 ～ -0.01])的相关性。快速身高增长与15岁时较低的FVC值和FVC1值相关。
   结论：幼儿期较快的体重增长与哮喘和气道高反应性相关，整个儿童时期较快的体重增长与较高的FVC和FEV1值相关。
 

（苏楠 审校）
JAllergyClinImmunol.2014Dec18.pii:S0091-6749(14)01589-9.doi:10.1016/j.jaci.2014.10.046. [Epub ahead of print]


 

Influence of childhood growth on asthma and lung function in adolescence.
 

Sonnenschein-van der Voort AM1, Howe LD2, Granell R3, Duijts L4, Sterne JA3, Tilling K3, Henderson AJ5.
 

Abstract
BACKGROUND: Low birth weight and rapid infant growth in early infancy are associated with increased risk of childhood asthma, but little is known about the role of postinfancy growth in asthmatic children.
OBJECTIVES: We sought to examine the associations of children's growth patterns with asthma, bronchial responsiveness, and lung function until adolescence.
METHODS: Individual growth trajectories from birth until 10 years of age were estimated by using linear spline multilevel models for 9723 children participating in a population-based prospective cohort study. Current asthma at 8, 14, and 17 years of age was based on questionnaires. Lung function and bronchial responsiveness or reversibility were measured during clinic visits at 8 and 15 years of age.
RESULTS: Rapid weight growth between 0 and 3 months of age was most consistently associated with increased risks of current asthma at the ages of 8 and 17 years, bronchial responsiveness at age 8 years, and bronchial reversibility at age 15 years. Rapid weight growth was associated with lung function values, with the strongest associations for weight gain between 3 and 7 years of age and higher forced vital capacity (FVC) and FEV1 values at age 15 years (0.12 [95% CI, 0.08 to 0.17] and 0.11 [95% CI, 0.07 to 0.15], z score per SD, respectively) and weight growth between 0 and 3 months of age and lower FEV1/FVC ratios at age 8 and 15 years (-0.13 [95% CI, -0.16 to -0.10] and -0.04 [95% CI, -0.07 to -0.01], z score per SD, respectively). Rapid length growth was associated with lower FVC and FVC1 values at age 15 years.
CONCLUSION: Faster weight growth in early childhood is associated with asthma and bronchial hyperresponsiveness, and faster weight growth across childhood is associated with higher FVC and FEV1 values.
 

JAllergyClinImmunol.2014Dec18.pii:S0091-6749(14)01589-9.doi:10.1016/j.jaci.2014.10.046. [Epub ahead of print]