哮喘联盟

   摘要
   背景：目前缺乏关于青少年过度换气综合征(HVS)的患病率数据。
   目的：旨在确定伴或不伴哮喘青少年群体中HVS的患病率，以评估HVS是否与哮喘活性相关。
   方法：要求青少年群体自行完成调查问卷，其中包括Nijmegen问卷以评估HVS和一份标准的哮喘调查问卷。
   结果：共有760份问卷适合于分析。其中120例受试者（15.8%）为哮喘患者。47例受试者（6.2%）的Nijmegen问卷得分≥23，提示患有HVS。哮喘受试者HVS的象征症状发生概率比不伴哮喘受试者高10倍（25% vs. 2.5%）。终生哮喘的受试者（P < 0.001）、现在新患哮喘的受试者（P < 0.05）以及目前活动性哮喘受试者（P < 0.001）的Nijmegen分数显著高于非哮喘受试者。在整个人群中，女孩HVS的患病率高于男孩（P < 0.001）。性别（女性的OR=3.2）和哮喘状况（终生哮喘OR=11.2；新患哮喘OR=8.9；目前活动性哮喘OR=41.5）对HVS发生概率具有显著的影响。
   结论：在未经选择的青少年群体中HVS象征症状的患病率比较高。女孩和哮喘受试者中症状更常见，且哮喘活动性对HVS发生概率有显著的影响。为了验证青少年和哮喘受试者中HVS的筛查工具，需要进一步的研究。
 

（苏楠 审校）
Pediatr Pulmonol. 2014 Dec 2. doi: 10.1002/ppul.23145. [Epub ahead of print]

 

Hyperventilation syndrome in adolescents with and without asthma.
 

D'Alba I1, Carloni I, Ferrante AL, Gesuita R, Palazzi ML, de Benedictis FM.
 

ABSTRACT
BACKGROUND: Data on the prevalence of hyperventilation syndrome (HVS) in adolescents are scanty.
OBJECTIVES: To determine the prevalence of HVS in a population of adolescents with and without asthma, and to verify whether HVS was related to asthma activity.
METHODS: A population of adolescents was asked to self-complete a questionnaire, including the Nijmegen questionnaire to assess HVS, and a standardized asthma questionnaire.
RESULTS: Seven hundred and sixty questionnaires were suitable for analysis. One hundred and twenty subjects (15.8%) were classified as asthmatic. Forty-seven subjects (6.2%) had a Nijmegen score ≥23, which was suggestive of HVS. Symptoms indicative of HVS were ten times more common in subjects with asthma (25%) than in those without asthma (2.5%). Nijmegen score was significantly higher in subjects with lifetime asthma (P < 0.001), current episodic asthma (P < 0.05) and current active asthma (P < 0.001) than in those with no asthma. In the whole population, girls presented HVS more frequently than boys (P < 0.001). There was a significant effect of gender (females, OR 3.2) and status of asthma (lifetime asthma, OR 11.2; current episodic asthma, OR 8.9; current active asthma, OR 41.5) on the probability of suffering from HVS.
CONCLUSIONS: The prevalence of symptoms indicative of HVS in an unselected population of adolescents was relatively high. Symptoms were more common in girls and in subjects with asthma, and there was a significant effect of asthma activity on the probability of suffering from HVS. Further studies need to be performed in order to validate a screening tool for HVS in both adolescents and asthmatic subjects.
 

Pediatr Pulmonol. 2014 Dec 2. doi: 10.1002/ppul.23145. [Epub ahead of print]