哮喘联盟

   摘要
   前言：目前对于慢性咳嗽患者治疗效果的准确评估方法仍然欠缺。本研究的目的是评估治疗后慢性咳嗽患者症状缓解的程度以及咳嗽发生的原因与治疗效果之间的关联性。
   材料与方法：我们通过逐步诊断法对成年、非吸烟慢性咳嗽患者的发病原因进行诊断。所有的患者均接受过特定的治疗方法。采用两种不同的问卷（一种视觉模拟量表和5度量表）对治疗前和治疗后4～6月的咳嗽严重程度进行评估。
   结果：两种问卷的调查结果均表明治疗前咳嗽的严重程度与治疗后咳嗽的严重程度间存在显著的相关性（两项问卷的Spearman相关系数分别为0.43，p = 0.0003和0.73，p < 0.0001）。基线的问卷分析结果表明，不同原因导致的咳嗽或多种原因导致的咳嗽患者之间的严重程度并没有显著差异。虽然从整体水平上来看，治疗后患者咳嗽的严重程度得到了明显的改善，但我们只看到了部分的好转。视觉模拟量表的评估结果显示，只有54.4%患者（37/68）咳嗽的严重程度下降50%以上。同样，5度量表的评估结果显示，只有54.4%的患者（37/68）咳嗽严重程度得到了满意的改善。此外，有三个亚组患者的咳嗽严重程度在治疗前后并没有得到显著的改善：1.同时具有3种咳嗽原因；2.非哮喘性嗜酸粒细胞性支气管炎；3.慢性特发性咳嗽。
   结论：患者咳嗽的严重程度并不依赖于其发病原因。对于非吸烟慢性咳嗽患者，治疗效果一般。
 

（刘国梁 审校）
Arch Med Sci. 2014 Oct 27;10(5):962-9. doi: 10.5114/aoms.2014.40642. Epub 2014 Oct 23.

 

Chronic cough - assessment of treatment efficacy based on two questionnaires.
 

Dąbrowska M1, Grabczak EM1, Arcimowicz M2, Domeracka-Kołodziej A2, Domagała-Kulawik J1, Krenke R1, Maskey-Warzęchowska M1, Tarchalska-Kryńska B3, Krasnodębska P1, Chazan R1.
 

ABSTRACT
INTRODUCTION: Efficacy of chronic cough treatment is ambiguous. The aim of the study was to analyze chronic cough alleviation after specific treatment and the relationship between cough etiology and treatment efficacy.
MATERIAL AND METHODS: A stepwise diagnostic approach was used to diagnose cough etiology in non-smoking adults with chronic cough. In all patients specific treatment was applied. Two different questionnaires - a visual analog scale and a 5-degree scale - were used to assess cough severity before and after 4-6 months of treatment.
RESULTS: A significant correlation between pre-treatment and post-treatment results of both questionnaires was found (Spearman coefficient 0.43, p = 0.0003 and 0.73, p < 0.0001, respectively). Baseline questionnaire analysis revealed no differences in cough severity between patients with different cough causes or multiple cough causes. Although specific treatment resulted in a significant decrease of cough severity in the entire group, only partial improvement was noted. According to the visual analogue scale, a decrease of cough severity by at least 50% was achieved only in 54.4% of patients (37/68). Similarly, satisfactory improvement was noted in only 54.4% (37/68) of patients when using the 5-point scale. There were three sub-groups of patients, in whom no relevant decrease of cough severity was observed despite treatment: patients with 1. three coexisting cough causes, 2. non-asthmatic eosinophilic bronchitis, and 3. chronic idiopathic cough.
CONCLUSIONS: Cough severity does not depend on its etiology. Efficacy of chronic cough treatment in non-smoking patients is only moderate.
 

Arch Med Sci. 2014 Oct 27;10(5):962-9. doi: 10.5114/aoms.2014.40642. Epub 2014 Oct 23.