哮喘联盟

   摘要
   前言：新发哮喘或原有哮喘的发作将使怀孕过程变得更加复杂和棘手。哮喘作为怀孕过程中最常见且最严重的医学难题之一，可能对母亲的生活质量和围产期结局产生不利影响。因此，在怀孕期间优化哮喘的治疗方式对于母亲和胎儿的健康都是非常重要的。
   研究范围：研究对孕妇人群中哮喘的发生和治疗方式进行了回顾性分析，并且密切关注了孕期哮喘药物治疗方式选择的主要原则。此外，本研究还对孕妇人群中常用哮喘药物治疗方法的安全性进行评估。本研究通过搜索电子文献数据库（如PUBMED等），纳入了最新发表的相关研究成果，搜索关键词为“pregnan*”/“perinat*”/“obstet*”、“asthma”/“wheeze”和“treatment”。
   专家意见：因为通常临床试验均把孕妇排除在外，所以关于孕期哮喘药物治疗方法的安全性评估还缺少足够的数据。未来最重要的需求之一便是获得一些孕期哮喘药物治疗安全性的信息并有助于哮喘控制。

 

（杨冬 审校）
Expert Opin Drug Saf. 2014 Nov 10:1-9. [Epub ahead of print]


 

Safety of therapeutic options for treating asthma in pregnancy.
 

Namazy JA1, Chambers C, Schatz M.
 

ABSTRACT
INTRODUCTION: Pregnancy may be complicated by new onset or preexisting asthma. Asthma is one of the most common potentially serious medical problems to complicate pregnancy, and it may adversely affect both maternal quality of life and perinatal outcomes. Optimal management of asthma during pregnancy is thus important for both mother and baby.
AREAS COVERED: This article reviews the recognition and management of asthma during pregnancy, paying close attention to the general principles of asthma medication use during pregnancy. Further, the article reviews the safety of asthma medications commonly used during pregnancy. In this article, the most pertinent recent publications are reported. Electronic databases, such as PUBMED, were searched for terms pregnan* or perinat* or obstet* and asthma or wheeze and treatment.
EXPERT OPINION: Because pregnant women are generally excluded from clinical trials, there is a lack of adequate safety information for most medications taken during pregnancy. One of the most important requirements for the future is the availability of further safety information for asthma medications used during pregnancy that can also account for asthma control.
 

Expert Opin Drug Saf. 2014 Nov 10:1-9. [Epub ahead of print]