哮喘联盟

   摘要
   研究目的：在全球范围内，慢性阻塞性肺疾病（COPD）和哮喘是发病和死亡的重要原因。它们主要影响肺，但是有着不同的肺外临床表现。本研究的目的是应用彩色多普勒超声评估COPD和哮喘患者眶周血管的血液动力学变化，并将结果与健康对照人群进行比较。
   研究方法：本研究共纳入37名COPD患者，37名哮喘患者和41名健康对照者。所有COPD患者均为中-重度COPD患者（根据GOLD标准），同样，哮喘患者均为中-重度持续性哮喘患者（根据GINA2006年指南）。对所有患者应用脉氧饱和度仪检测呼气末二氧化碳含量、外周血氧饱和度、脉率以及呼吸频率。每位受试者仅随机检测一个眼的眶周血管超声。应用彩色多普勒超声技术检测视网膜中央动脉、睫状后动脉、鼻后睫动脉的收缩期峰值流速、舒张末期血流速度以及阻力指数。
   结果：与对照组相比，COPD患者和哮喘患者的睫状后动脉、鼻后睫动脉的收缩期峰值流速、舒张末期血流速度以及阻力指数显著升高，COPD患者与哮喘患者间相比无差异。
   结论：我们认为COPD和哮喘患者的眶后血液动力学改变是这两种疾病的系统性效应之一。
 

（杨冬 审校）
J Investig Med. 2014 Nov 10. [Epub ahead of print]


 

Evaluation of Arterial Blood Flow Changes by Orbital Doppler in Chronic Obstructive Pulmonary Disease and Asthma.
 

Yakut ZI1, Karadağ R, Ozol D, Senturk A.
 

Abstract
PURPOSE: Both chronic obstructive pulmonary disease (COPD) and asthma are important causes of morbidity and mortality worldwide. They primarily affect the lungs, but they have various extrapulmonary manifestations. The aim of our study was to evaluate the hemodynamic changes in orbital vessels of the patients with COPD and asthma using color Doppler ultrasonography and compare the results with healthy control subjects.
METHODS: Thirty-seven patients with COPD, 37 patients with asthma, and 41 healthy control subjects were included in this study. All patients with COPD were in moderate to severe group according to GOLD (Global Initiative for Chronic Obstructive Lung Disease), and similarly, all patients with asthma were in moderate to severe persistent group according to GINA (Global Initiative for Asthma) 2006 guidelines. End-tidal carbon dioxide, peripheral oxygen saturation, pulse rate, and respiratory rate were measured by using pulse oximeter in all patients. Measurements were performed in only 1 randomly selected eye of each participant. The peak systolic velocity, end diastolic velocity, and resistance index were measured in the central retinal artery, temporal posterior ciliary artery, and nasal posterior ciliary artery using the color Doppler ultrasonography technique.
RESULTS: The peak systolic velocity, end diastolic velocity, and resistance index values of temporal posterior ciliary artery and nasal posterior ciliary artery were significantly higher in COPD and asthma than in the control subjects. There was no difference between asthma and COPD.
CONCLUSIONS: We concluded that retrobulbar hemodynamics change in COPD and asthma is showing 1 of the systemic effects in these diseases.
 

J Investig Med. 2014 Nov 10. [Epub ahead of print]